Rabbit anti-Human ABL2 Polyclonal Antibody | anti-ABL2 antibody

Rabbit Polyclonal to Human ABL2

Cat. Num. AAA248514

• Gene Names: ABL2; ARG; ABLL
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: ABL2; Polyclonal Antibody; Rabbit Polyclonal to Human ABL2; Anti-ABL2 Antibody (Tyr251) IHC-plus; Abl-related gene ARG; ABLL; Abelson-related gene protein; ARG; Oncogene abl2; Tyrosine-protein kinase ARG; Human ABL2; anti-ABL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS with 0.09% (w/v) sodium azide
• Sequence Length: 1182

• Applicable Applications for anti-ABL2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (1:1000)
• Target Species: Human
• Immunogen Description: KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.
• Immunogen Type: Synthetic peptide
• Immunogen: ABL2 antibody was raised against kLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.
• Antigen Modification: Tyr251
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-ABL2 antibody IHC staining of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(Western blot of anti-ABL Antibody (Y251) in A2058 cell line lysates (35 ug/lane). ABL(arrow) was detected using the purified Pab.)

Related Product Information for anti-ABL2 antibody

ABL2, an Abl type protein kinase, regulates cellular morphogenesis and motility. ABL2 also is associated with the development and function of the central nervous system. ABL2 (-/-) mice develop normally but exhibit multiple behavioral abnormalities, likely resulting from defects in neuronal function. At least two mRNA transcripts, resulting in different protein isoforms of 1146 and 1182 amino acids, have been reported.

Product Categories/Family for anti-ABL2 antibody

Family: Protein Kinase; Subfamily: Abl

NCBI and Uniprot Product Information

• NCBI GI #: 6382062
• NCBI GeneID: 27
• NCBI Accession #: NP_009298.1
• NCBI GenBank Nucleotide #: NM_007314.3
• UniProt Accession #: P42684; Q5T0X6; Q5W0C5; Q6NZY6; Q7Z301; A0M8X0; B7UEF2; B7UEF3; B7UEF4; B7UEF5
• Molecular Weight: 60,864 Da
• NCBI Official Full Name: Abelson tyrosine-protein kinase 2 isoform b
• NCBI Official Synonym Full Names: ABL proto-oncogene 2, non-receptor tyrosine kinase
• NCBI Official Symbol: ABL2
• NCBI Official Synonym Symbols: ARG; ABLL
• NCBI Protein Information: Abelson tyrosine-protein kinase 2; tyrosine-protein kinase ARG; abelson-related gene protein; c-abl oncogene 2, non-receptor tyrosine kinase; v-abl Abelson murine leukemia viral oncogene homolog 2
• UniProt Protein Name: Abelson tyrosine-protein kinase 2
• Protein Family: Abelson tyrosine-protein kinase
• UniProt Gene Name: ABL2
• UniProt Synonym Gene Names: ABLL; ARG
• UniProt Entry Name: ABL2_HUMAN

NCBI Description

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Uniprot Description

Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TK; EC 2.7.10.2; Oncoprotein; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Abl family

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: extrinsic to internal side of plasma membrane; lamellipodium; dendritic spine; cytosol; phagocytic cup; actin cytoskeleton

Molecular Function: actin filament binding; actin monomer binding; protein binding; protein-tyrosine kinase activity; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; magnesium ion binding; ATP binding; receptor binding; protein kinase activity

Biological Process: axon guidance; peptidyl-tyrosine phosphorylation; positive regulation of protein binding; cerebellum morphogenesis; alpha-beta T cell differentiation; platelet-derived growth factor receptor signaling pathway; signal transduction; regulation of apoptosis; elevation of cytosolic calcium ion concentration; Bergmann glial cell differentiation; regulation of endocytosis; visual learning; neuromuscular process controlling balance; positive regulation of oxidoreductase activity; regulation of cell adhesion; epidermal growth factor receptor signaling pathway; actin filament bundle formation; cell migration; positive regulation of I-kappaB kinase/NF-kappaB cascade; dendrite morphogenesis; protein modification process; substrate-bound cell migration, cell extension; phagocytosis; regulation of cell proliferation; negative regulation of Rho protein signal transduction; innate immune response; regulation of autophagy; negative regulation of cell-cell adhesion; neuron remodeling