Rabbit anti-Human, Mouse ABCE1 Polyclonal Antibody | anti-ABCE1 antibody

ABCE1 Antibody

Cat. Num. AAA9629279

• Gene Names: ABCE1; RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: ABCE1; Polyclonal Antibody; ABCE1 Antibody; 2' 5' oligoadenylate binding protein; 2''-5''-oligoadenylate-binding protein; 2'5' oligoadenylate binding protein; ABC 38; ABC38; ABCE 1; ABCE1_HUMAN; ATP binding cassette sub family E (OABP) member 1; ATP binding cassette sub family E member 1; ATP-binding cassette sub-family E member 1; HuHP 68; HuHP68; OABP; Ribonuclease 4 inhibitor; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor; Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor; Ribonuclease L inhibitor; RLI; RNase L inhibitor; RNASEL1; RNASELI; RNS 4I; RNS4I; anti-ABCE1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: ABCE1 Antibody detects endogenous levels of total ABCE1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-ABCE1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: Belongs to the ABC transporter superfamily. ABCE family.
• Subunit Structure: Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL.(Microbial infection) Interacts with HIV-1 proteins Vif and Gag.(Microbial infection) Interacts with HIV-2 protein Gag.
• Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2', 5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
• Note: Localized to clusters of virus formation at the plasma membrane.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-ABCE1 antibody

Cytoplasm; Mitochondrion; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 108773784
• NCBI GeneID: 6059
• NCBI Accession #: NP_001035809.1
• NCBI GenBank Nucleotide #: NM_001040876.1
• UniProt Accession #: P61221; O88793; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66
• Molecular Weight: 67,314 Da
• NCBI Official Full Name: ATP-binding cassette sub-family E member 1
• NCBI Official Synonym Full Names: ATP binding cassette subfamily E member 1
• NCBI Official Symbol: ABCE1
• NCBI Official Synonym Symbols: RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI
• NCBI Protein Information: ATP-binding cassette sub-family E member 1
• UniProt Protein Name: ATP-binding cassette sub-family E member 1
• Protein Family: ABC transporter E family
• UniProt Gene Name: ABCE1
• UniProt Synonym Gene Names: RLI; RNASEL1; RNASELI; RNS4I; RNS4I

NCBI Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family.

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytoplasm; eukaryotic translation initiation factor 3 complex; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; iron ion binding; protein binding; ribosomal small subunit binding

Biological Process: ribosome export from nucleus; translational initiation; translational termination; transmembrane transport