Tissue Specific Transplantation Antigen (TSTAg) ELISA Kit | TSTAg elisa kit

Plant Tissue Specific Transplantation Antigen (TSTAg) ELISA Kit

• Gene Names: HLA-C; MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3
• Reactivity: Plant
• Synonyms: Tissue Specific Transplantation Antigen (TSTAg); Plant Tissue Specific Transplantation Antigen (TSTAg) ELISA Kit; TSTAg elisa kit

• Reactivity: Plant
• Sequence Length: 342

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 386777
• NCBI GeneID: 3107
• Molecular Weight: 40,965 Da
• NCBI Official Full Name: transplantation antigen, partial
• NCBI Official Synonym Full Names: major histocompatibility complex, class I, C
• NCBI Official Symbol: HLA-C
• NCBI Official Synonym Symbols: MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3
• NCBI Protein Information: HLA class I histocompatibility antigen, Cw-1 alpha chain
• UniProt Protein Name: HLA class I histocompatibility antigen, Cw-1 alpha chain
• UniProt Gene Name: HLA-C
• UniProt Synonym Gene Names: HLAC
• UniProt Entry Name: 1C01_HUMAN

NCBI Description

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]

Uniprot Description

HLAC iso2: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane

Molecular Function: antigen binding; peptide antigen binding

Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; regulation of immune response

Disease: Psoriasis 1, Susceptibility To