Typical Testing Data/Standard Curve (for reference only)
Rat Cytosolic phospholipase A2 ELISA Kit | Pla2g4a elisa kit
Rat Cytosolic phospholipase A2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
catalyzes the synthesis of COX-2 substrate arachidonic acid (AA); may play a role in epileptogenesis [RGD, Feb 2006]
Uniprot Description
cPLA2: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Arachidonic acid is a precursor for the eicosanoids that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Promotes cerebellar long-term depression and motor learning. Translocates to the Golgi and endoplasmic reticulum in a calcium-dependent fashion. Translocation and activation of at the ER facilitates the process of ER stress. Regulates the biogenesis of lipid droplets, a process dependent on JNK and ceramide kinase. Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Inhibited when in trimolecular complex with ANXA2 and S100A10. Phosphorylation of S727 relieves this inhibitory interaction, thus activating PLA2G4A.
Protein type: Lipid Metabolism - linoleic acid; Phospholipase; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - alpha-linolenic acid; EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; intracellular membrane-bound organelle; nucleus; perinuclear region of cytoplasm
Molecular Function: calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; histone acetyltransferase binding; lysophospholipase activity; phospholipase A2 activity
Biological Process: aging; arachidonic acid metabolic process; arachidonic acid secretion; decidualization; icosanoid biosynthetic process; luteolysis; ovulation from ovarian follicle; phospholipid catabolic process; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of fever; positive regulation of inflammatory response; positive regulation of prostaglandin biosynthetic process; positive regulation of vesicle fusion; regulation of cell proliferation; response to calcium ion; response to glucocorticoid stimulus; response to heat; response to hormone stimulus; response to hydrogen peroxide; response to lipopolysaccharide; response to lithium ion; response to methylmercury; response to organic nitrogen; response to organic substance; response to vitamin D; surfactant homeostasis
Research Articles on Pla2g4a
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Product Notes
The Rat Pla2g4a pla2g4a (Catalog #AAA2880731) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880731 ELISA Kit recognizes Rat Pla2g4a. It is sometimes possible for the material contained within the vial of "Cytosolic phospholipase A2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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