Piwi-like protein 1 (PIWIL1) Recombinant Protein | PIWIL1 recombinant protein

Recombinant Chicken Piwi-like protein 1 (PIWIL1), partial

• Gene Names: PIWIL1; PIWI
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Piwi-like protein 1 (PIWIL1); Recombinant Chicken Piwi-like protein 1 (PIWIL1); partial; PIWIL1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 867

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for PIWIL1 recombinant protein

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.

NCBI and Uniprot Product Information

• NCBI GI #: 149642713
• NCBI GeneID: 416804
• NCBI Accession #: NP_001092322.1
• NCBI GenBank Nucleotide #: NM_001098852.1
• UniProt Accession #: A6N7Y9
• Molecular Weight: 99,286 Da
• NCBI Official Full Name: piwi-like protein 1
• NCBI Official Synonym Full Names: piwi like RNA-mediated gene silencing 1
• NCBI Official Symbol: PIWIL1
• NCBI Official Synonym Symbols: PIWI
• NCBI Protein Information: piwi-like protein 1
• UniProt Protein Name: Piwi-like protein 1
• Protein Family: Piwi-like protein
• UniProt Gene Name: PIWIL1

Uniprot Description

Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs ().