Membrane-associated phosphatidylinositol transfer protein 1 Recombinant Protein | PITPNM1 recombinant protein

Recombinant Human Membrane-associated phosphatidylinositol transfer protein 1

Cat. Num. AAA717052

• Gene Names: PITPNM1; Rd9; NIR2; RDGB; DRES9; RDGB1; RDGBA; PITPNM; RDGBA1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Membrane-associated phosphatidylinositol transfer protein 1; Recombinant Human Membrane-associated phosphatidylinositol transfer protein 1; Drosophila retinal degeneration B homolog; Phosphatidylinositol transfer protein; membrane-associated 1; PITPnm 1; Pyk2 N-terminal domain-interacting receptor 2; NIR-2; PITPNM1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 1-238aa; Partial
• Sequence: MLIKEYHILLPMSLDEYQVAQLYMIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHVGSHIPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYYLPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRLYHSVKTGRGPLSDDWARTAAQTGPLMCAYKLCKVEFRYWGMQAKIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSM
• Sequence Length: 1243

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for PITPNM1 recombinant protein

Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. 4 Publications

Product Categories/Family for PITPNM1 recombinant protein

Transport

References

A mammalian homologue of the Drosophila retinal degeneration B gene implications for the evolution of phototransduction mechanisms.Rubboli F., Bulfone A., Bogni S., Marchitiello A., Zollo M., Borsani G., Ballabio A., Banfi S.Genes Funct. 1:205-213(1997) Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.Lev S., Hernandez J., Martinez R., Chen A., Plowman G., Schlessinger J.Mol. Cell. Biol. 19:2278-2288(1999) Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3.Ocaka L., Spalluto C., Wilson D.I., Hunt D.M., Halford S.Cytogenet. Genome Res. 108:293-302(2005) Human chromosome 11 DNA sequence and analysis including novel gene identification.Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.Nature 440:497-500(2006)

NCBI and Uniprot Product Information

• NCBI GI #: 195927017
• NCBI GeneID: 9600
• NCBI Accession #: NP_001124320.1
• NCBI GenBank Nucleotide #: NM_001130848.1
• UniProt Accession #: O00562; Q6T7X3; Q8TBN3; Q9BZ73; A6NME4
• Molecular Weight: 54.5 kDa
• NCBI Official Full Name: membrane-associated phosphatidylinositol transfer protein 1 isoform b
• NCBI Official Synonym Full Names: phosphatidylinositol transfer protein, membrane associated 1
• NCBI Official Symbol: PITPNM1
• NCBI Official Synonym Symbols: Rd9; NIR2; RDGB; DRES9; RDGB1; RDGBA; PITPNM; RDGBA1
• NCBI Protein Information: membrane-associated phosphatidylinositol transfer protein 1
• UniProt Protein Name: Membrane-associated phosphatidylinositol transfer protein 1
• Protein Family: Membrane-associated phosphatidylinositol transfer protein
• UniProt Gene Name: PITPNM1
• UniProt Synonym Gene Names: DRES9; NIR2; PITPNM; PITPnm 1; NIR-2
• UniProt Entry Name: PITM1_HUMAN

NCBI Description

PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]

Uniprot Description

PITPNM1: putatively transfers phosphatidylinositol and phosphatidylcholine between membranes. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Has higher affinity for the inactive, GDP-bound form of RHOA. Necessary for normal completion of cytokinesis and for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. Interacts with PIK4CA and with Pyk2 via its C-terminus. Phosphorylated on multiple sites by CDC2 at the onset of mitosis. CDC2-phosphorylated forms may interact with PLK1. Interacts with VAPB. Phosphorylated on threonine residues upon treatment with oleic acid.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cleavage furrow; cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane; midbody

Molecular Function: metal ion binding; phosphatidylinositol transporter activity; protein binding

Biological Process: brain development; lipid metabolic process; phospholipid transport; phototransduction; protein transport