Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between CD247 and DOCK2. HeLa cells were stained with CD247 rabbit purified polyclonal 1:1200 and DOCK2 mouse monoclonal antibody 1:50. Signals were detected by Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
Mouse anti-Human DOCK2 Monoclonal Antibody | anti-DOCK2 antibody
DOCK2 (Dedicator Of Cytokinesis 2, FLJ46592, KIAA0209)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between CD247 and DOCK2. HeLa cells were stained with CD247 rabbit purified polyclonal 1:1200 and DOCK2 mouse monoclonal antibody 1:50. Signals were detected by Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between CD247 and DOCK2. HeLa cells were stained with CD247 rabbit purified polyclonal 1:1200 and DOCK2 mouse monoclonal antibody 1:50. Signals were detected by Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Uniprot Description
DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described.
Protein type: Adaptor/scaffold; GAPs, Rac/Rho; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: cytoskeleton; membrane; endomembrane system; cytosol
Molecular Function: protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding
Biological Process: alpha-beta T cell proliferation; viral reproduction; formation of immunological synapse; myeloid dendritic cell activation during immune response; positive regulation of phagocytosis; small GTPase mediated signal transduction; establishment of T cell polarity; actin cytoskeleton organization and biogenesis; lipid raft polarization; chemotaxis; negative thymic T cell selection; regulation of defense response to virus by virus; positive thymic T cell selection
Disease: Immunodeficiency 40
Research Articles on DOCK2
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Product Notes
The DOCK2 dock2 (Catalog #AAA6009941) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DOCK2 (Dedicator Of Cytokinesis 2, FLJ46592, KIAA0209) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DOCK2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Researchers should empirically determine the suitability of the DOCK2 dock2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MCVCAEDGKT LPVAVPIEDM QRIHLRFMFR HRSSLESKDK GEKNFAMSYV KLMKEDGTTL HDGFHDLVVL KGDSKKMEDA SAYLTLPSYR HHVENKGATL SRSSSSVGGL SVSSRDVFSI STLVCSTKLT QNVGLLGLLK WRMKPQLEES MRRLFESINN LMKSQYKTTI LLQVAALKYI PSVLHDVEMV FDAKLLSQLL YEFYTCIPPV KLQKQKVQSM NEIVQSNLFK KQECRDILLP VITKELKELL EQKDDMQHQV LERKYCVELL NSILEVLSYQ DAAFTYHHIQ EIMVQLLRTV NRTVITMGRD HILIGACCNC GFPSSTPHSL IQWLWG. It is sometimes possible for the material contained within the vial of "DOCK2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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