Mouse PHD finger protein 2 ELISA Kit | PHF2 elisa kit
Mouse Lysine-specific demethylase PHF2, PHF2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PHF2: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Component of the PHF2-ARID5B complex, at least composed of PHF2 and ARID5B. Interacts with HNF4A and NR1H4. Widely expressed, including in liver. Enzymatically inactive by itself, and become active following phosphorylation by PKA. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
Protein type: EC 1.14.11.-; Nucleolus
Cellular Component: kinetochore; cytoplasm; nucleolus; chromosome; nucleus; chromosome, pericentric region
Molecular Function: procollagen-proline dioxygenase activity; 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity; sulfonate dioxygenase activity; zinc ion binding; dioxygenase activity; iron ion binding; metal ion binding; transcription coactivator activity; DNA-N1-methyladenine dioxygenase activity; oxidoreductase activity; histone demethylase activity (H3-K9 specific); methylated histone residue binding
Biological Process: histone H3-K9 demethylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification; protein amino acid demethylation
Research Articles on PHF2
Similar Products
Product Notes
The Mouse PHF2 phf2 (Catalog #AAA9336619) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336619 ELISA Kit recognizes Mouse PHF2. It is sometimes possible for the material contained within the vial of "PHD finger protein 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
