Peptidase D/PEPD Recombinant Protein | PEPD recombinant protein

Recombinant Human Peptidase D/PEPD Protein

Cat. Num. AAA2553068

• Gene Names: PEPD; PROLIDASE
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Peptidase D/PEPD; Recombinant Human Peptidase D/PEPD Protein; Xaa-Pro dipeptidase; Imidodipeptidase; PeptidaseD; Prolinedipeptidase; PRD; PEPD; PEPD recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Supplied as a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Ala2-Lys493
• Sequence Length: 493

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Preparation and Storage: Store at < -20 degree C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.

Related Product Information for PEPD recombinant protein

PEPD belongs to the peptidase M24B family of Eukaryotic-type prolidase subfamily. PEPD is a cytosolic dipeptidase that hydrolyzes dipeptides with proline or hydroxyproline at the carboxy terminus. It is important in collagen metabolism because of the high levels of imino acids. Defects in PEPD are a cause of prolidase deficiency which is an autosomal recessive disorder associated with iminodipeptiduria.

NCBI and Uniprot Product Information

• NCBI GI #: 149589008
• NCBI GeneID: 5184
• NCBI Accession #: NP_000276.2
• NCBI GenBank Nucleotide #: NM_000285.3
• UniProt Accession #: P12955; Q8TBN9; Q9BT75; A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8
• Molecular Weight: Molecular Mass: 54.5 kDa; Actual Protein Molecular Mass: 60 kDa
• NCBI Official Full Name: xaa-Pro dipeptidase isoform 1
• NCBI Official Synonym Full Names: peptidase D
• NCBI Official Symbol: PEPD
• NCBI Official Synonym Symbols: PROLIDASE
• NCBI Protein Information: xaa-Pro dipeptidase
• UniProt Protein Name: Xaa-Pro dipeptidase
• Protein Family: Dipeptidase
• UniProt Gene Name: PEPD
• UniProt Synonym Gene Names: PRD; X-Pro dipeptidase; Prolidase

NCBI Description

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Description

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.