Testing Data
PEAK1 recombinant protein
PEAK1, Active
For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Testing Data
Testing Data
Testing Data #2
Testing Data #2
Scientific Background: PEAK1 or Pseudopodium-enriched atypical kinase 1 is a protein tyrosine kinase which belongs to NKF3 kinase family and regulates the cytoskeleton and has been shown to be involved in cancer progression (1). PEAK1 promotes anchorage-independent growth in the MDA-MB-435 human cancer cell line and promotes tumor progression of XPA-1 human pancreatic cancer cells when transplanted into the pancreas of nude mice. PEAK1 is highly expressed in spleen, followed by heart, ovary, brain, lung, kidney, and fetal brain (2).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Uniprot Description
PEAK1: a cytoskeleton-associated non-receptor tyrosine kinase that localizes to focal adhesions and actin filaments. Operates downstream of integrin and epidermal growth factor receptors, regulating the P130Cas-Crk-PXN and MAPK signaling. In the late stages of EGF signaling, SGK269 mediates Shc1 protein interactions involved in and cell spreading, migration, and morphogenesis. Amplified in a large fraction of colon cancer. Influences anchorage-independent growth and tumor progression in mice.
Protein type: EC 2.7.10.2; Kinase, protein; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: actin cytoskeleton; focal adhesion
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding
Biological Process: cell migration; protein amino acid autophosphorylation
Research Articles on PEAK1
Similar Products
Product Notes
The PEAK1 peak1 (Catalog #AAA515575) is a Recombinant Protein produced from Sf9 insect cells using baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1127-end. AAA Biotech's PEAK1 can be used in a range of immunoassay formats including, but not limited to, Kinase Assay, Western Blot (WB). Researchers should empirically determine the suitability of the PEAK1 peak1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PEAK1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
