Parkinson Disease Protein 7 Recombinant Protein | PARK7 recombinant protein

Recombinant Mouse Parkinson Disease Protein 7

Cat. Num. AAA141169

• Gene Names: Park7; Dj1; DJ-1
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Parkinson Disease Protein 7; Recombinant Mouse Parkinson Disease Protein 7; PARK7 Mouse; Parkinson Disease Protein 7 Mouse Recombinant; Protein deglycase DJ-1; Parkinson disease protein 7 homolog; PARK7 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: PARK7 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMASKRAL VILAKGAEEM ETVIPVDVMR RAGIKVTVAG LAGKDPVQCSRDVMICPDTS LEDAKTQGPY DVVVLPGGNL GAQNLSESPM VKEILKEQES RKGLIAAICA GPTALLAHEVGFGCKVTTHP LAKDKMMNGS HYSYSESRVE KDGLILTSRGPGTSFEFALA IVEALVGKDM ANQVKAPLVL KD
• Sequence Length: 189

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. ; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles.

Related Product Information for PARK7 recombinant protein

Introduction: The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).

Description: PARK7 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-189 a.a) and having a molecular mass of 22.4kDa. PARK7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for PARK7 recombinant protein

Recombinant & Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 55741460
• NCBI GeneID: 57320
• NCBI Accession #: NP_065594.2
• NCBI GenBank Nucleotide #: NM_020569.3
• UniProt Accession #: Q99LX0; O88306; Q3THB9; Q3U509
• Molecular Weight: 20,021 Da
• NCBI Official Full Name: protein DJ-1
• NCBI Official Synonym Full Names: Parkinson disease (autosomal recessive, early onset) 7
• NCBI Official Symbol: Park7
• NCBI Official Synonym Symbols: Dj1; DJ-1
• NCBI Protein Information: protein deglycase DJ-1
• UniProt Protein Name: Protein deglycase DJ-1
• Protein Family: Protein deglycase
• UniProt Gene Name: Park7
• UniProt Entry Name: PARK7_MOUSE

Uniprot Description

DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.

Protein type: EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor

Cellular Component: axon; cell-cell adherens junction; chromatin; cytoplasm; cytosol; endoplasmic reticulum; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; PML body

Molecular Function: androgen receptor binding; copper ion binding; cytokine binding; enzyme binding; identical protein binding; kinase binding; mercury ion binding; mRNA binding; oxidoreductase activity, acting on peroxide as acceptor; peptidase activity; peroxiredoxin activity; protein binding; protein homodimerization activity; receptor binding; RNA binding; superoxide dismutase copper chaperone activity; transcription coactivator activity; transcription factor binding

Biological Process: adult locomotory behavior; cell proliferation; detoxification of copper ion; detoxification of mercury ion; dopamine uptake; enzyme active site formation via L-cysteine sulfinic acid; glycolate biosynthetic process; hydrogen peroxide metabolic process; lactate biosynthetic process; membrane depolarization; membrane hyperpolarization; methylglyoxal metabolic process; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of protein catabolic process; negative regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; positive regulation of interleukin-8 production; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein deglycosylation; protein stabilization; regulation of inflammatory response; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; response to hydrogen peroxide; response to oxidative stress; synaptic transmission, dopaminergic