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Activity (Specific Activity : Sample activity data. For lot specific data please refer to the specific datasheet.)

PAK2 (Y443N) Recombinant Protein | PAK2 recombinant protein

PAK2 (Y443N), Active

Synonyms
PAK2 (Y443N); Active; PAK65; PAKgamma; PAK2 recombinant protein
Ordering
For Research Use Only!
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
Tag
GST
Species
Human
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Activity

(Specific Activity : Sample activity data. For lot specific data please refer to the specific datasheet.)

Activity (Specific Activity : Sample activity data. For lot specific data please refer to the specific datasheet.)

SDS-Page

(Purity: Sample purity data. for lot-specific data please refer to the specific datasheet.)

SDS-Page (Purity: Sample purity data. for lot-specific data please refer to the specific datasheet.)
Related Product Information for PAK2 recombinant protein
Recombinant full-length human PAK2 (Y443N) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_002577.
PAK2 proteins is a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK2 (Y443N) is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell (1). The CDC42 and RAC1 induce autophosphorylation of PAK2 (Y443N), which stimulates sustained phosphorylation of other substrates (2).
References
1. Koeppel, M. A. et.al: Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. J. Biol. Chem. 279: 53653-53664, 2004.
2. Martin, G. A. et.al: A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14: 1970-1978, 1995.

NCBI and Uniprot Product Information

NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
approx. MW: 95kDa

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Product Notes

The PAK2 (Catalog #AAA517361) is a Recombinant Protein produced from Sf9 insect cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PAK2 (Y443N), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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