Mouse Oxidized low-density lipoprotein receptor 1 ELISA Kit | Olr1 elisa kit

Mouse Oxidized low-density lipoprotein receptor 1 ELISA Kit

Cat. Num. AAA762042

• Gene Names: Olr1; LOX-1; Oldr1; Oldlr1
• Reactivity: Mouse
• Synonyms: Oxidized low-density lipoprotein receptor 1; Mouse Oxidized low-density lipoprotein receptor 1 ELISA Kit; Olr1/LOX-1/LOX1/CLEC8A/SCARE1/SR-E1/SLOX1/C-type lectin domain family 8 member A/Lectin-like oxidized LDL receptor 1/Lectin-like oxLDL receptor 1/Lectin-type oxidized LDL receptor 1/ox LDL receptor 1/LOXIN/oxidised low density lipoprotein (lectin-like) receptor 1/oxidized low-density lipoprotein receptor 1/Ox-LDL receptor 1/scavenger receptor class E; member 1; Olr1 elisa kit

• Reactivity: Mouse
• Sequence Length: 368

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 0.78-50ng/ml
• Sensitivity: 0.469ng/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Testing Data

Typical Standard Curve

Related Product Information for Olr1 elisa kit

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Mouse Olr1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Mouse Olr1 antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRP-Streptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Mouse Olr1 amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of Mouse Olr1 can be calculated.

NCBI and Uniprot Product Information

• NCBI GI #: 404247470
• NCBI GeneID: 140914
• NCBI Accession #: NP_579840.2
• NCBI GenBank Nucleotide #: NM_133306.2
• Molecular Weight: 41,890 Da
• NCBI Official Full Name: oxidized low-density lipoprotein receptor 1
• NCBI Official Synonym Full Names: oxidized low density lipoprotein (lectin-like) receptor 1
• NCBI Official Symbol: Olr1
• NCBI Official Synonym Symbols: LOX-1; Oldr1; Oldlr1
• NCBI Protein Information: oxidized low-density lipoprotein receptor 1
• UniProt Protein Name: Oxidized low-density lipoprotein receptor 1
• Protein Family: Oxidized low-density lipoprotein receptor
• UniProt Gene Name: Olr1
• UniProt Synonym Gene Names: Lox1; Oldlr1; Ox-LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1
• UniProt Entry Name: OLR1_RAT

NCBI Description

receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006]

Uniprot Description

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.