Typical Testing Data/Standard Curve (for reference only)
Rat oxidized low density lipoprotein, OxLDL ELISA Kit | OxLDL elisa kit
Rat oxidized low density lipoprotein, OxLDL ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with Rat OXLDL antibody. OXLDL present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Rat OXLDL Antibody is added and binds to OXLDL in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated OXLDL antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Rat OXLDL. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
NCBI and Uniprot Product Information
NCBI Description
receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006]
Uniprot Description
Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Ref.2 Ref.4
Subunit structure: Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70
By similarity.
Subcellular location: Cell membrane; Lipid-anchor
By similarity. Cell membrane; Single-pass type II membrane protein
By similarity. Membrane raft
By similarity. Secreted
By similarity. Note: A secreted form also exists. Localization to membrane rafts requires palmitoylation
By similarity.
Tissue specificity: Predominantly expressed in lung and at lower level in kidney. Expressed in macrophages but not in vascular smooth muscle cells. Ref.1
Induction: By hypertension. Up-regulated by shear stress, lipopolysaccharide and TNF-alpha in cultured vascular endothelial cells. Ref.1 Ref.2
Domain: The cytoplasmic region is required for subcellular sorting on the cell surface
By similarity.The C-type lectin domain mediates the recognition and binding of oxLDL
By similarity.The Neck region contains 3 internal repeats that are only found in rodents.
Post-translational modification: N-glycosylated
By similarity.
Sequence similarities: Contains 1 C-type lectin domain.
Research Articles on OxLDL
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Product Notes
The Rat OxLDL olr1 (Catalog #AAA1605169) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1605169 ELISA Kit recognizes Rat OxLDL. It is sometimes possible for the material contained within the vial of "oxidized low density lipoprotein, OxLDL, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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