Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) Recombinant Protein | OCRL recombinant protein

Recombinant Human Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) , partial

• Gene Names: OCRL; LOCR; NPHL2; OCRL1; INPP5F; OCRL-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL); Recombinant Human Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL); partial; OCRL recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 901

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for OCRL recombinant protein

This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

NCBI and Uniprot Product Information

• NCBI GI #: 13325072
• NCBI GeneID: 4952
• NCBI Accession #: NP_000267.2
• NCBI GenBank Nucleotide #: NM_000276.3
• UniProt Accession #: Q01968; O60800; Q15684; Q15774; Q4VY09; Q4VY10; Q5JQF1; Q5JQF2; Q9UJG5; A6NKI1; A8KAP2; B7ZLX2
• Molecular Weight: 103,227 Da
• NCBI Official Full Name: inositol polyphosphate 5-phosphatase OCRL-1 isoform a
• NCBI Official Synonym Full Names: OCRL, inositol polyphosphate-5-phosphatase
• NCBI Official Symbol: OCRL
• NCBI Official Synonym Symbols: LOCR; NPHL2; OCRL1; INPP5F; OCRL-1
• NCBI Protein Information: inositol polyphosphate 5-phosphatase OCRL-1
• UniProt Protein Name: Inositol polyphosphate 5-phosphatase OCRL-1
• Protein Family: Inositol polyphosphate 5-phosphatase
• UniProt Gene Name: OCRL
• UniProt Synonym Gene Names: INPP5F; OCRL1

NCBI Description

This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976).