CLEC2D recombinant protein

CLEC2D Protein, Rat, Recombinant (hFc Tag)

Cat. Num. AAA8123404

• Gene Names: Clec2d; Ocil; Clec2d5
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CLEC2D; CLEC2D Protein; Rat; Recombinant (hFc Tag); Rat CLEC2D/OCIL Protein (Fc Tag); C-type lectin domain family 2; member D; CLEC2D recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Lys98-Leu233

• Species: Rat
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Glu
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the rat CLEC2D (NP_569086.1)(Lys98-Leu233) was expressed with Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CLEC2D recombinant protein

Background: Lectin-like transcript 1 (LLT1) encoded by CLEC2D gene is a C-type lectin-like molecule interacting with human CD161 (NKR-P1A) receptor expressed by natural killer cells and subsets of T cells. CLEC2D transcripts were detected primarily in hematopoietic cell lines and were found to be co-induced by the same activation signals. Although very low amounts of putative soluble CLEC2D protein isoforms could be produced by transfectants, CLEC2D isoforms 2 and 4 were efficiently expressed. CLEC2D uses gene splicing to generate protein isoforms that are structurally distinct and that have different biological activities. Prostate cancer is the most common type of cancer identified and the second leading cause of cancer-related death in American men. Natural Killer (NK) cells are the first line of defense against cancer and infections. NK cell function is regulated by a delicate balance between signals received through activating and inhibitory receptors. Previously, we identified Lectin-like transcript-1 (LLT1/OCIL/CLEC2D) as a counter-receptor for the NK cell inhibitory receptor NKRP1A (CD161). Interaction of LLT1 expressed on target cells with NKRP1A inhibits NK cell activation.

NCBI and Uniprot Product Information

• NCBI GI #: 18426818
• NCBI GeneID: 113937
• NCBI Accession #: NP_569086.1
• NCBI GenBank Nucleotide #: NM_130402.2
• UniProt Accession #: Q925N7
• Molecular Weight: 25,686 Da
• NCBI Official Full Name: C-type lectin domain family 2 member D5
• NCBI Official Synonym Full Names: C-type lectin domain family 2, member D
• NCBI Official Symbol: Clec2d
• NCBI Official Synonym Symbols: Ocil; Clec2d5
• NCBI Protein Information: C-type lectin domain family 2 member D5
• UniProt Protein Name: C-type lectin domain family 2 member D5
• Protein Family: C-type lectin domain family
• UniProt Gene Name: Ocil
• UniProt Synonym Gene Names: Clec2d5

NCBI Description

mouse homolog inhibits osteoclast formation [RGD, Feb 2006]

Uniprot Description

Lectin-type cell surface receptor.