KIR2DL3 recombinant protein

KIR2DL3 Protein, Human, Recombinant (ECD, hFc Tag)

Cat. Num. AAA8121227

• Gene Names: KIR2DL3; p58; NKAT; GL183; NKAT2; CD158b; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB
• Purity: >90% as determined by SDS-PAGE
• Synonyms: KIR2DL3; KIR2DL3 Protein; Human; Recombinant (ECD; hFc Tag); Human KIR2DL3 (CD158b2) Protein (Fc Tag); CD158b Protein; CD158B2 Protein; CU464054.1 Protein; GL183 Protein; KIR-023GB Protein; KIR-K7b Protein; KIR-K7c Protein; KIR2DS5 Protein; KIRCL23 Protein; MGC129943 Protein; NKAT Protein; NKAT2 Protein; NKAT2A Protein; NKAT2B Protein; p58 Protein; killer cell immunoglobulin like receptor; two Ig domains and long cytoplasmic tail 3; KIR2DL3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-His245

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: His 22
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human KIR2DL3 (AAX23102.1)(Met1-His245) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for KIR2DL3 recombinant protein

Background: Killer cell immunoglobulin-like receptor 2DL3, also known as CD158 antigen-like family member B2, KIR-23GB, Killer inhibitory receptor cl 2-3, MHC class I NK cell receptor, NKAT2a, NKAT2b, Natural killer-associated transcript 2, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158b2, and KIR2DL3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. KIR2DL3 contains 2 Ig-like C2-type (immunoglobulin-like) domains. KIR2DL3 interacts with ARRB2. KIR2DL3 is a receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3, and HLA-Cw7). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

Product Categories/Family for KIR2DL3 recombinant protein

ITIM/ITAM Immunoreceptors and Related Molecules

References

Selvakumar A., et al., 1997, Immunol. Rev. 155:183-196. Wilson M.J., et al., 1997, Tissue Antigens 49:574-579. Maenaka K., et al., 1999, Structure 7:391-398. Vitale,M. et al., 2004, Int Immunol. 16 (10):1459-66. Yu M.-C., et al., 2008, Nat. Immunol. 9:898-907.

NCBI and Uniprot Product Information

• NCBI GI #: 60546065
• NCBI GeneID: 3804
• Molecular Weight: 27,269 Da
• NCBI Official Full Name: natural killer cell inhibitory receptor
• NCBI Official Synonym Full Names: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
• NCBI Official Symbol: KIR2DL3
• NCBI Official Synonym Symbols: p58; NKAT; GL183; NKAT2; CD158b; NKAT2A; NKAT2B; CD158B2; KIR-K7b; KIR-K7c; KIR2DS5; KIRCL23; KIR-023GB
• NCBI Protein Information: killer cell immunoglobulin-like receptor 2DL3
• Protein Family: Killer cell immunoglobulin-like receptor

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]