OAT recombinant protein

OAT, 33-439aa, Human, E Coli

Cat. Num. AAA203639

• Gene Names: OAT; OKT; GACR; HOGA; OATASE
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: OAT; 33-439aa; Human; E Coli; ornithine aminotransferase precursor; DKFZp781A11155; HOGA; OATASE; ornithine aminotransferase precursor EC 2.6.1.13; ornithine aminotransferase (gyrate atrophy); Ornithine aminotransferase; mitochondrial precursor; Ornithine oxo-acid aminotransferase; Ornithine--oxo-acid aminotransferase.; OAT recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
• Concentration: 1.0 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MTVQGPPTSD DIFEREYKYG AHNYHPLPVA LERGKGIYLW DVEGRKYFDF LSSYSAVNQG HCHPKIVNAL KSQVDKLTLT SRAFYNNVLG EYEEYITKLF NYHKVLPMNT GVEAGETACK LARKWGYTVK GIQKYKAKIV FAAGNFWGRT LSAISSSTDP TSYDGFGPFM PGFDIIPYND LPALERALQD PNVAAFMVEP IQGEAGVVVP DPGYLMGVRE LCTRHQVLFI ADEIQTGLAR TGRWLAVDYE NVRPDIVLLG KALSGGLYPV SAVLCDDDIM LTIKPGEHGS TYGGNPLGCR VAIAALEVLE EENLAENADK LGIILRNELM KLPSDVVTAV RGKGLLNAIV IKETKDWDAW KVCLRLRDNG LLAKPTHGDI IRFAPPLVIK EDELRESIEI INKTILSF
• Sequence Length: 439

• Applicable Applications for OAT recombinant protein: SDS-PAGE
• Antigen Species: Human
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for OAT recombinant protein

OAT, also known as mitochondrial enzyme ornithine aminotransferase, is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. (L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.) Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Recombinant OAT protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for OAT recombinant protein

Enzymes & Proteases

References

Mitchell GA., et al. (1988) J. Biol. Chem. 263 (28):14288-95.; Shah SA., et al. (1997) Structure. 5 (8):1067-75;

NCBI and Uniprot Product Information

• NCBI GI #: 4557809
• NCBI GeneID: 4942
• NCBI Accession #: NP_000265
• NCBI GenBank Nucleotide #: NM_000274.3
• UniProt Accession #: P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03; D3DRF0
• Molecular Weight: 45.2 kDa (408aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: ornithine aminotransferase, mitochondrial isoform 1
• NCBI Official Synonym Full Names: ornithine aminotransferase
• NCBI Official Symbol: OAT
• NCBI Official Synonym Symbols: OKT; GACR; HOGA; OATASE
• NCBI Protein Information: ornithine aminotransferase, mitochondrial
• UniProt Protein Name: Ornithine aminotransferase, mitochondrial
• UniProt Gene Name: OAT

NCBI Description

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]