Neuropeptide Y Receptor Y1 Assay System | NPY1R assay system
Neuropeptide Y Receptor Y1 (NPY1R) ACTOne Stable Cell Line
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Uniprot Description
NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q31.3-q32
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity
Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; glucose metabolic process; regulation of multicellular organism growth; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain
Research Articles on NPY1R
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Product Notes
The NPY1R npy1r (Catalog #AAA433659) is an Assay System and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent assay for Gi-coupled human NPY1R; cell-based high-throughput screening of human NPY1R inhibitors. Researchers should empirically determine the suitability of the NPY1R npy1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neuropeptide Y Receptor Y1, Assay System" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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