NCBI and Uniprot Product Information
NCBI Description
binds natriuretic peptide receptor; involved in inhibition of growth and proliferation in vascular smooth muscle cells [RGD, Feb 2006]
Uniprot Description
NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.
Protein type: Secreted; Secreted, signal peptide; Hormone
Cellular Component: extracellular space; secretory granule
Molecular Function: hormone activity; peptide hormone receptor binding; protein homodimerization activity; receptor binding
Biological Process: cGMP biosynthetic process; negative regulation of cell proliferation; negative regulation of DNA metabolic process; negative regulation of meiotic cell cycle; organ development; ossification; positive regulation of cGMP biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of vasodilation; post-embryonic development; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process; regulation of multicellular organism growth; regulation of smooth muscle cell proliferation; response to drug; response to ethanol; response to hypoxia
Research Articles on Nppc
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Product Notes
The Rat Nppc nppc (Catalog #AAA2887369) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2887369 ELISA Kit recognizes Rat Nppc. It is sometimes possible for the material contained within the vial of "C-type natriuretic peptide, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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