Human C-type natriuretic peptide ELISA Kit | NPPC elisa kit

Human C-type natriuretic peptide ELISA Kit

Cat. Num. AAA2883056

• Gene Names: NPPC; CNP; CNP2
• Reactivity: Human
• Synonyms: C-type natriuretic peptide; Human C-type natriuretic peptide ELISA Kit; NPPC; CNP2; NPPC elisa kit

• Reactivity: Human
• Sequence Length: 126

• Assay Type: Competitive
• Detection Range: 7.8-500 pg/mL
• Sensitivity: 3.9 pg/mL
• Intra-Assay CV: <=4.2%
• Inter-Assay CV: <=7.9%
• Recovery: 99%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 13249346
• NCBI GeneID: 4880
• NCBI Accession #: NP_077720.1
• NCBI GenBank Nucleotide #: NM_024409.3
• UniProt Accession #: P23582; Q4ZG41
• Molecular Weight: 13,246 Da
• NCBI Official Full Name: C-type natriuretic peptide preproprotein
• NCBI Official Synonym Full Names: natriuretic peptide C
• NCBI Official Symbol: NPPC
• NCBI Official Synonym Symbols: CNP; CNP2
• NCBI Protein Information: C-type natriuretic peptide
• UniProt Protein Name: C-type natriuretic peptide
• Protein Family: C-type natriuretic peptide
• UniProt Gene Name: NPPC
• UniProt Synonym Gene Names: CNP2
• UniProt Entry Name: ANFC_HUMAN

NCBI Description

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]

Uniprot Description

NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: extracellular region; extracellular space; secretory granule

Molecular Function: hormone activity; peptide hormone receptor binding; protein homodimerization activity; receptor binding

Biological Process: cGMP biosynthetic process; negative regulation of cell proliferation; negative regulation of DNA metabolic process; negative regulation of meiotic cell cycle; ossification; positive regulation of cGMP biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of vasodilation; post-embryonic development; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process; regulation of multicellular organism growth; regulation of smooth muscle cell proliferation; response to drug; response to ethanol; response to hypoxia