NALP8 Blocking Peptide | NLRP8 blocking peptide

NALP8 Peptide

Cat. Num. AAA151874

• Gene Names: NLRP8; PAN4; NALP8; NOD16; CLR19.2
• Applications: Blocking (BL)
• Synonyms: NALP8; NALP8 Peptide; PAN4; NOD16; CLR19.2; NACHT; LRR and PYD domains-containing protein 8; Nucleotide-binding oligomerization domain protein 16; NLR family; pyrin domain containing 8; NLRP8 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1048

• Applicable Applications for NLRP8 blocking peptide: Blocking (BL)
• Application Notes: NALP8 peptide is used for blocking the activity of NALP8 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human NALP8.
• Preparation and Storage: Store NALP8 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 33667040
• NCBI GeneID: 126205
• NCBI Accession #: NP_789781
• NCBI GenBank Nucleotide #: NM_176811.2
• UniProt Accession #: Q86W28; Q7RTR4
• Molecular Weight: 117,336 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 8
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 8
• NCBI Official Symbol: NLRP8
• NCBI Official Synonym Symbols: PAN4; NALP8; NOD16; CLR19.2
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 8; PYRIN and NACHT-containing protein 4; NACHT, LRR and PYD containing protein 8; NACHT, leucine rich repeat and PYD containing 8; nucleotide-binding oligomerization domain protein 16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 8
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP8
• UniProt Synonym Gene Names: NALP8; NOD16; PAN4
• UniProt Entry Name: NALP8_HUMAN

NCBI Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP8: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: cytoplasm

Molecular Function: ATP binding