NF-kappa-B inhibitor zeta (NFKBIZ) Recombinant Protein | NFKBIZ recombinant protein

Recombinant Bovine NF-kappa-B inhibitor zeta (NFKBIZ) , partial

• Gene Names: NFKBIZ; MAIL
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: NF-kappa-B inhibitor zeta (NFKBIZ); Recombinant Bovine NF-kappa-B inhibitor zeta (NFKBIZ); partial; NFKBIZ recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 719

• Species: Bovine
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for NFKBIZ recombinant protein

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 41386701
• NCBI GeneID: 282713
• NCBI Accession #: NP_777151.1
• NCBI GenBank Nucleotide #: NM_174726.1
• UniProt Accession #: Q9BE45; A7Z059
• Molecular Weight: 78,239 Da
• NCBI Official Full Name: NF-kappa-B inhibitor zeta
• NCBI Official Synonym Full Names: NFKB inhibitor zeta
• NCBI Official Symbol: NFKBIZ
• NCBI Official Synonym Symbols: MAIL
• NCBI Protein Information: NF-kappa-B inhibitor zeta
• UniProt Protein Name: NF-kappa-B inhibitor zeta
• Protein Family: NF-kappa-B inhibitor
• UniProt Gene Name: NFKBIZ
• UniProt Synonym Gene Names: MAIL; IkB-zeta; IkappaBzeta; MAIL

Uniprot Description

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis ().