Rabbit CCAR1 Polyclonal Antibody | anti-CCAR1 antibody

CCAR1 Polyclonal Antibody

Cat. Num. AAA2527945

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CCAR1; Polyclonal Antibody; CCAR1 Polyclonal Antibody; RP11-437A18.1; anti-CCAR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.9mg/mL (varies by lot)
• Sequence Length: 1135

• Applicable Applications for anti-CCAR1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant protein of human CCAR1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using CCAR1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CCAR1 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-CCAR1 antibody

Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene. The deduced 1, 150-amino acid CARP1 protein contains a putative cold-shock protein domain expected to bind RNA and a putative DNA-binding motif predicted to be involved in chromosomal organization. Immunohistochemical analysis detected CARP1 in the perinuclear compartment of human breast cancer cells, and the protein had an apparent molecular mass of 130 kD by SDS-PAGE.

Product Categories/Family for anti-CCAR1 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 545479138
• NCBI GeneID: 55749
• NCBI Accession #: NP_001269888.1
• NCBI GenBank Nucleotide #: NM_001282959.1
• Molecular Weight: 131,043 Da
• NCBI Official Full Name: cell division cycle and apoptosis regulator protein 1 isoform b
• NCBI Official Synonym Full Names: cell division cycle and apoptosis regulator 1
• NCBI Official Symbol: CCAR1
• NCBI Protein Information: cell division cycle and apoptosis regulator protein 1; cell cycle and apoptosis regulatory protein 1; death inducer with SAP domain
• UniProt Protein Name: Cell division cycle and apoptosis regulator protein 1
• Protein Family: Cell division cycle and apoptosis regulator protein
• UniProt Gene Name: CCAR1
• UniProt Synonym Gene Names: CARP1; DIS; CARP-1
• UniProt Entry Name: CCAR1_HUMAN

Uniprot Description

CCAR1: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Nuclear receptor co-regulator; RNA splicing

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: nucleoplasm; perinuclear region of cytoplasm

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; RNA splicing; gene expression; cell cycle