Guinea Pig nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) ELISA Kit | NFKB2 elisa kit
Guinea Pig nuclear factor NF-kappa-B p100 subunit, NFKB2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
NFkB-p100: a transcription factor of the nuclear factor-kappaB ( NFkB) group. Precursor of the p52 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two spliced isoforms have been identified. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Cellular Component: Bcl3/NF-kappaB2 complex; nucleoplasm; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; DNA binding; chromatin binding; transcription factor activity
Biological Process: spleen development; transcription from RNA polymerase II promoter; I-kappaB kinase/NF-kappaB cascade; extracellular matrix organization and biogenesis; transcription, DNA-dependent; cellular response to stress; follicular dendritic cell differentiation; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; lymph node development; regulation of transcription, DNA-dependent; response to cytokine stimulus; germinal center formation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; inflammatory response
Research Articles on NFKB2
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Product Notes
The Guinea Pig NFKB2 nfkb2 (Catalog #AAA9310903) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9310903 ELISA Kit recognizes Guinea Pig NFKB2. It is sometimes possible for the material contained within the vial of "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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