Typical Testing Data/Standard Curve (for reference only)
Human Nuclear receptor corepressor 1 ELISA Kit | NCOR1 elisa kit
Human Nuclear receptor corepressor 1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Uniprot Description
N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; perinuclear region of cytoplasm; Sin3 complex; spindle microtubule; transcription factor complex; transcriptional repressor complex
Molecular Function: chromatin binding; estrogen receptor binding; histone deacetylase binding; histone deacetylase regulator activity; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; retinoid X receptor binding; sequence-specific DNA binding; thyroid hormone receptor binding; transcription corepressor activity; transcription factor activity
Biological Process: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; cellular lipid metabolic process; cerebellum development; cholesterol homeostasis; chromatin modification; circadian regulation of gene expression; circadian rhythm; establishment and/or maintenance of chromatin architecture; gene expression; lactation; negative regulation of JNK cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of cell proliferation; positive regulation of histone deacetylation; regulation of multicellular organism growth; skeletal muscle development; spindle assembly; thalamus development; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway
Research Articles on NCOR1
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Product Notes
The Human NCOR1 ncor1 (Catalog #AAA2885184) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2885184 ELISA Kit recognizes Human NCOR1. It is sometimes possible for the material contained within the vial of "Nuclear receptor corepressor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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