Human Augmenter of Liver Regeneration ELISA Kit | ALR elisa kit

Human Augmenter of Liver Regeneration ELISA Kit

Cat. Num. AAA11262

• Gene Names: GFER; ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1
• Reactivity: Human
• Synonyms: Augmenter of Liver Regeneration; Human Augmenter of Liver Regeneration ELISA Kit; ALR elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between Human ALR and analogues was observed.

• Samples: Serum, Plasma, Tissue Homogenate, Feces, Urine and Body Fluids
• Assay Type: Sandwich
• Detection Range: 125 pg/ml ~ 4000 pg/ml.
• Sensitivity: 10 pg/ml.
• Intended Uses: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate ALR concentrations in Human serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research, not for drug, household, therapeutic applications
• Intra-assay Precision: Intra-assay CV (%) are less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean x100]
• Preparation and Storage: Store all reagents at 2-8 degree C

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ALR elisa kit

Introduction: ELISA is a simple and highly sensitive method of analysis that allows for simultaneous and rapid quantification of a large number of samples. The assay is based on the specific recognition of the target compound (analyte/antigen) by antibodies which bind to the compound. The antigen-antibody complex is detected and measured with the aid of an enzyme-labeled antibody or antigen. Upon addition of a non-colored reagent, the enzyme produces a color reaction where the color intensity is directly or inversely proportional to the concentration of the analyte in the sample. This quantitative Sandwich ELISA kit is in tended to determinate ALR concentrations in Human serum, plasma, tissue homogenates, feces, urine and body fluids, and it is only for research!

NCBI and Uniprot Product Information

• NCBI GI #: 4995963
• NCBI GeneID: 2671
• UniProt Accession #: P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40
• Molecular Weight: 23,449 Da
• NCBI Official Full Name: augmenter of liver regeneration
• NCBI Official Synonym Full Names: growth factor, augmenter of liver regeneration
• NCBI Official Symbol: GFER
• NCBI Official Synonym Symbols: ALR; HPO; HSS; ERV1; HPO1; HPO2; HERV1
• NCBI Protein Information: FAD-linked sulfhydryl oxidase ALR; ERV1 homolog; hepatopoietin protein; erv1-like growth factor; hepatic regenerative stimulation substance
• UniProt Protein Name: FAD-linked sulfhydryl oxidase ALR
• Protein Family: Alanine racemase
• UniProt Gene Name: GFER
• UniProt Synonym Gene Names: ALR; HERV1; HPO; hERV1
• UniProt Entry Name: ALR_HUMAN

NCBI Description

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GFER: Isoform 1: FAD-dependent sulfhydryl oxidase. Within the mitochondrial intermembrane space, participates in a chain of disulfide exchange reactions with MIA40, that generate disulfide bonds in a number of resident proteins with twin Cx3C and Cx9C motifs. Defects in GFER are a cause of mitochondrial progressive myopathy with congenital cataract hearing loss and developmental delay (MPMCHD); also called combined mitochondrial complex deficiency. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Oxidoreductase; EC 1.8.3.2

Chromosomal Location of Human Ortholog: 16p13.3-p13.12

Cellular Component: mitochondrion; cytoplasm; extracellular region; mitochondrial intermembrane space

Molecular Function: protein binding; growth factor activity; FAD binding; thiol oxidase activity; protein disulfide oxidoreductase activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion

Disease: Myopathy, Mitochondrial Progressive, With Congenital Cataract, Hearing Loss, And Developmental Delay