Mouse murine retrovirus integration site 1 homolog ELISA Kit | MRVI1 elisa kit
Mouse Protein MRVI1, MRVI1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein participates in signaling by nitric oxide (NO) to inhibit intracellular calcium release and platelet aggregation in cardiovascular tissue. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Uniprot Description
MRVI1: Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Membrane protein, integral
Cellular Component: sarcoplasmic reticulum; membrane; cytoplasm; integral to membrane; intracellular
Molecular Function: protein binding
Biological Process: relaxation of vascular smooth muscle; cGMP-mediated signaling; negative regulation of smooth muscle contraction
Research Articles on MRVI1
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Product Notes
The Mouse MRVI1 mrvi1 (Catalog #AAA9330759) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330759 ELISA Kit recognizes Mouse MRVI1. It is sometimes possible for the material contained within the vial of "murine retrovirus integration site 1 homolog, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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