Rabbit anti-Human NURR1 Polyclonal Antibody | anti-NURR1 antibody

NURR1 polyclonal antibody

Cat. Num. AAA3015848

• Gene Names: NR4A2; NOT; RNR1; HZF-3; NURR1; TINUR
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Synonyms: NURR1; Polyclonal Antibody; NURR1 polyclonal antibody; Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor; NR4A2; NOT; TINUR; anti-NURR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: NURR1 polyclonal antibody detects endogenous levels of NURR1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Applicable Applications for anti-NURR1 antibody: Western Blot (WB)
• Application Notes: WB: 1:2000~1:5000
• Immunogen: Synthetic peptide, corresponding to Human NURR1.
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of NURR1 polyclonal antibody at 1:2000 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug))

Related Product Information for anti-NURR1 antibody

Nurr1 (Nur-related factor 1) and Nur77 (also designated NGFI-B) encodeorphan nuclear receptors which may comprise an additional subfamily withinthe nuclear receptor superfamily. The rat and human homologs of mouse Nurr1are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growthfactor inducible, immediate early response genes. Induction of both Nurr1 andNur77 is seen after membrane depolarization while only Nur77 induction isseen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nurr77 expression is seen in activated T cells during G0 to G1 transition andthroughout the G1 phase. In addition to its function as an immediate earlygene, Nur77 may play a role in TCR-mediated apoptosis. Cyclosporin A, apotent immuno-suppressant, has been shown to inhibit the ability of Nur77to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation-induced apoptosis. However, the absolute requirementof Nur77 for TCR-mediated apoptosis is still under debate.

NCBI and Uniprot Product Information

• NCBI GI #: 187423888
• NCBI GeneID: 4929
• NCBI Accession #: NP_006177.1
• NCBI GenBank Nucleotide #: NM_006186
• UniProt Accession #: P43354; Q16311; Q53RZ2; Q6NXU0
• Molecular Weight: 59,809 Da
• NCBI Official Full Name: Homo sapiens nuclear receptor subfamily 4, group A, member 2 (NR4A2), mRNA
• NCBI Official Synonym Full Names: nuclear receptor subfamily 4, group A, member 2
• NCBI Official Symbol: NR4A2
• NCBI Official Synonym Symbols: NOT; RNR1; HZF-3; NURR1; TINUR
• NCBI Protein Information: nuclear receptor subfamily 4 group A member 2; NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor related 1; nur related protein-1,
• UniProt Protein Name: Nuclear receptor subfamily 4 group A member 2
• UniProt Gene Name: NR4A2
• UniProt Synonym Gene Names: NOT; NURR1; TINUR
• UniProt Entry Name: NR4A2_HUMAN

NCBI Description

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons ().