Mouse anti-Human UBN1 Antibody | anti-UBN1 antibody

Anti-UBN1 Purified

Cat. Num. AAA1801638

• Gene Names: TRAT1; TRIM; TCRIM; HSPC062; pp29/30
• Reactivity: Human
• Applications: Immunoprecipitation, Western Blot
• Purity: Purified by Protein-A Affinity Chromatography
• Synonyms: UBN1; Anti-UBN1 Purified; ubinuclein 1; Ubinuclein 1; VT4; anti-UBN1 antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG
• Clone Number: UBN1-02
• Specificity: The antibody UBN1-02 recognizes N-terminal part of ubinuclein 1 (UBN1), a widely expressed nuclear and adhesion complex protein. Western blotting analysis reveals UBN1 as a 165 kDa band.
• Purity/Purification: Purified by Protein-A Affinity Chromatography
• Form/Format: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 186

• Applicable Applications for anti-UBN1 antibody: Immunoprecipitation, Western Blot (WB)
• Immunogen: Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1.
• Preparation and Storage: Store at 2-8 degree C.

Western Blot (WB)

(Western blotting analysis of ubinuclein in nuclear fraction of HeLa cells. The monoclonal antibody UBN1-01 (lane A, B) detects ubinuclein 1 (165 kDa) and an 180 kDa protein - presumable ubinuclein 2. The antibody UBN1-02 (lane C, D) detects ubinuclein 1. Antibody dilution: A, C - 1 ug/ml; B, D - 5 ug/ml.)

Related Product Information for anti-UBN1 antibody

Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.

NCBI and Uniprot Product Information

• NCBI GI #: 54607137
• NCBI GeneID: 50852
• NCBI Accession #: NP_057472.2
• NCBI GenBank Nucleotide #: NP_057472.2
• UniProt Accession #: Q6PIZ9
• NCBI Official Full Name: T-cell receptor-associated transmembrane adapter 1 isoform 1
• NCBI Official Synonym Full Names: T cell receptor associated transmembrane adaptor 1
• NCBI Official Symbol: TRAT1
• NCBI Official Synonym Symbols: TRIM; TCRIM; HSPC062; pp29/30
• NCBI Protein Information: T-cell receptor-associated transmembrane adapter 1
• UniProt Protein Name: T-cell receptor-associated transmembrane adapter 1
• Protein Family: Ubinuclein
• UniProt Gene Name: TRAT1
• UniProt Synonym Gene Names: TCRIM; TRIM
• UniProt Entry Name: TRAT1_HUMAN

Uniprot Description

TRAT1: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of T cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of calcium-mediated signaling; negative regulation of receptor recycling; negative regulation of transport; signal transduction; T cell receptor signaling pathway