Western Blot (WB)
(Western blot analysis Ubinuclein using LOVO whole cell lysates)
Rabbit anti-Human, Mouse Ubinuclein Polyclonal Antibody | anti-UBN1 antibody
Ubinuclein Antibody
Gene Names
UBN1; VT; VT4
Reactivity
Human, Mouse
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
Ubinuclein; Polyclonal Antibody; Ubinuclein Antibody; Ubinuclein 1; Ubiquitously expressed nuclear protein; VT; VT4; anti-UBN1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Ubinuclein antibody detects endogenous levels of total Ubinuclein
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
1134
Applicable Applications for anti-UBN1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human Ubinuclein
Subcellular Location
Nuclear
Tissue Specificity
Ubiquitous. Also expressed in numerous tumors and cancer cell lines.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis Ubinuclein using LOVO whole cell lysates)
Western Blot (WB)
(Western blot analysis Ubinuclein using LOVO whole cell lysates)
Related Product Information for anti-UBN1 antibody
Function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Subunit Structure: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.
Similarity: Belongs to the ubinuclein family.
Subunit Structure: Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.
Similarity: Belongs to the ubinuclein family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 121 kDa
Predicted: 122 kDa
Predicted: 122 kDa
NCBI Official Full Name
ubinuclein-1 isoform a
NCBI Official Synonym Full Names
ubinuclein 1
NCBI Official Symbol
UBN1
NCBI Official Synonym Symbols
VT; VT4
NCBI Protein Information
ubinuclein-1
UniProt Protein Name
Ubinuclein-1
Protein Family
UniProt Gene Name
UBN1
NCBI Description
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]
Uniprot Description
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Research Articles on UBN1
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Product Notes
The UBN1 ubn1 (Catalog #AAA9609190) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ubinuclein Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ubinuclein can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the UBN1 ubn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ubinuclein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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