Flow Cytometry (FC/FACS)
(Flow cytometry analysis (intracellular staining) of human peripheral blood with mAb TRIM-04 PE.)
Mouse anti-Human TRIM Antibody | anti-TRIM antibody
Anti-TRIM PE
Gene Names
TRAT1; TRIM; TCRIM; HSPC062; pp29/30
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Synonyms
TRIM; Anti-TRIM PE; T cell receptor associated transmembrane adaptor 1; TRAT; TCRIM; anti-TRIM antibody
Host
Mouse
Reactivity
Human
Isotype
IgG2a
Clone Number
TRIM-04
Specificity
The antibody TRIM-04 recognizes an intracellular epitope of T cell receptor-interacting molecule (TRIM), a 30 kDa adaptor protein expressed by T cells.
Purity/Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Concentration
0.1 mg/ml (varies by lot)
Sequence Length
186
Applicable Applications for anti-TRIM antibody
Flow Cytometry (FC/FACS)
Application Notes
FC/FACS: QC tested
Immunogen
Recombinant intracellular domain (aa 29-186) of human TRIM.
Negative Species
Mouse
Conjugation
PE
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Flow Cytometry (FC/FACS)
(Flow cytometry analysis (intracellular staining) of human peripheral blood with mAb TRIM-04 PE.)
Flow Cytometry (FC/FACS)
(Flow cytometry analysis (intracellular staining) of human peripheral blood with mAb TRIM-04 PE.)
Related Product Information for anti-TRIM antibody
TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
T-cell receptor-associated transmembrane adapter 1 isoform 1
NCBI Official Synonym Full Names
T cell receptor associated transmembrane adaptor 1
NCBI Official Symbol
TRAT1
NCBI Official Synonym Symbols
TRIM; TCRIM; HSPC062; pp29/30
NCBI Protein Information
T-cell receptor-associated transmembrane adapter 1
UniProt Protein Name
T-cell receptor-associated transmembrane adapter 1
Protein Family
UniProt Gene Name
TRAT1
UniProt Synonym Gene Names
TCRIM; TRIM
UniProt Entry Name
TRAT1_HUMAN
Uniprot Description
TRAT1: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
Protein type: Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3q13
Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane
Molecular Function: transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of T cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of calcium-mediated signaling; negative regulation of receptor recycling; negative regulation of transport; signal transduction; T cell receptor signaling pathway
Research Articles on TRIM
Similar Products
Product Notes
The TRIM trat1 (Catalog #AAA1801607) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-TRIM PE reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). FC/FACS: QC tested. Researchers should empirically determine the suitability of the TRIM trat1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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