Mouse anti-Human SNCG Antibody | anti-SNCG antibody

SNCG Antibody (breast cancer-specific protein 1)

Cat. Num. AAA850341

• Gene Names: SNCG; SR; BCSG1
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, ELISA
• Synonyms: SNCG; SNCG Antibody (breast cancer-specific protein 1); SR; BCSG1; anti-SNCG antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG1
• Clone Number: 1H10D2
• Form/Format: Purified antibody in PBS containing 0.03% sodium azide.
• Sequence Length: 127

• Applicable Applications for anti-SNCG antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of SNCG expressed in E. Coli.
• Preparation and Storage: Store at 4 degree C, for long term storage, store at-20 degree C

Western Blot (WB)

(Figure 1. Western blot analysis using SNCG mouse mAb against truncated SNCG recombinant protein.)

Immunohistochemistry (IHC)

(Figure 2. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma (left) and breast carcinoma (right), showing cytoplasmic(ovary carcinoma) localization, cytoplasmic and nuclear (breast carcinoma) localization using SNCG mouse mAb with DAB staining.)

Related Product Information for anti-SNCG antibody

SNCG(also designated gamma-synuclein or breast cancer-specific protein 1), with 127-amino acid protein(about 14kDa), belongs to the synuclein family, which also includes alpha-and beta-synuclein.Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.

Product Categories/Family for anti-SNCG antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 209693439
• NCBI GeneID: 6623
• NCBI Accession #: NP_003078.2
• NCBI GenBank Nucleotide #: NM_003087.2
• UniProt Accession #: O76070; O15104; Q96P61
• Molecular Weight: 13,331 Da
• NCBI Official Full Name: gamma-synuclein isoform 1
• NCBI Official Synonym Full Names: synuclein gamma
• NCBI Official Symbol: SNCG
• NCBI Official Synonym Symbols: SR; BCSG1
• NCBI Protein Information: gamma-synuclein
• UniProt Protein Name: Gamma-synuclein
• Protein Family: Gamma-synuclein
• UniProt Gene Name: SNCG
• UniProt Synonym Gene Names: BCSG1; PERSYN; PRSN; SR

NCBI Description

This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

Uniprot Description

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway ().