Rabbit anti-Human SNCG / Gamma-Synuclein Polyclonal Antibody | anti-SNCG antibody

Rabbit Polyclonal (IgG) to Human SNCG / Gamma-Synuclein

Cat. Num. AAA243108

• Gene Names: SNCG; SR; BCSG1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: SNCG / Gamma-Synuclein; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human SNCG / Gamma-Synuclein; Anti-SNCG / Gamma-Synuclein Antibody IHC-plus; SNCG; BCSG1; Gamma-synuclein; PRSN; SR; PERSYN; Synoretin; Human SNCG; Gamma-Synuclein; anti-SNCG antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified
• Form/Format: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 127

• Applicable Applications for anti-SNCG antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:200), WB (1:2000)
• Target Species: Human
• Immunogen Description: Recombinant human protein purified from E Coli (His-gamma Synuclein).
• Immunogen Type: Recombinant protein
• Immunogen: SNCG / Gamma-Synuclein antibody was raised against recombinant human protein purified from E Coli (His-gamma Synuclein).
• Preparation and Storage: Long term: -20 degree C; Short term: -20 degree C

Immunohistochemistry (IHC)

(Anti-Gamma-Synuclein / SNCG antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Immunohistochemistry (IHC)

(Anti-Gamma-Synuclein / SNCG antibody IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Western Blot (WB)

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Related Product Information for anti-SNCG antibody

Synuclein-gamma is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.

NCBI and Uniprot Product Information

• NCBI GI #: 209693439
• NCBI GeneID: 6623
• NCBI Accession #: NP_003078.2
• NCBI GenBank Nucleotide #: NM_003087.2
• UniProt Accession #: O76070; O15104; Q96P61
• Molecular Weight: 13,331 Da
• NCBI Official Full Name: gamma-synuclein
• NCBI Official Synonym Full Names: synuclein, gamma (breast cancer-specific protein 1)
• NCBI Official Symbol: SNCG
• NCBI Official Synonym Symbols: SR; BCSG1
• NCBI Protein Information: gamma-synuclein; persyn; synoretin; breast cancer-specific gene 1 protein
• UniProt Protein Name: Gamma-synuclein
• Protein Family: Gamma-synuclein
• UniProt Gene Name: SNCG
• UniProt Synonym Gene Names: BCSG1; PERSYN; PRSN; SR
• UniProt Entry Name: SYUG_HUMAN

NCBI Description

This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]

Uniprot Description

SNCG: a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. May be involved in modulating axonal architecture during development and in the adult. Plays a role in neurofilament network integrity. High levels have been identified in advanced breast carcinomas.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23.2-q23.3

Cellular Component: cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; microtubule organizing center; spindle; nerve terminal

Molecular Function: beta-tubulin binding; alpha-tubulin binding

Biological Process: response to drug; synaptic transmission; adult locomotory behavior; synapse organization and biogenesis; protein secretion; regulation of neurotransmitter secretion; response to cocaine; regulation of dopamine secretion