Western Blot (WB)
(Figure 1: Western blot analysis using SNCG mouse mAb against truncated SNCG recombinant protein.)
Mouse anti-Human SNCG Monoclonal Antibody | anti-SNCG antibody
SNCG (breast cancer-specific protein 1) Antibody
Gene Names
SNCG; SR; BCSG1
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunofluorescence, Immunocytochemistry, ELISA
Purity
Affinity-Chromatography
Synonyms
SNCG; Monoclonal Antibody; SNCG (breast cancer-specific protein 1) Antibody; BCSG1; Breast cancer specific gene 1 protein; Breast cancer specific protein 1; Breast cancer-specific gene 1 protein; Gamma synuclein; Gamma-synuclein; Persyn; PRSN; SR; Synoretin; Synuclein gamma; synuclein; gamma (breast cancer-specific protein 1); SYUG_HUMAN; anti-SNCG antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Specificity
SNCG (breast cancer-specific protein 1) antibody detects endogenous levels of total SNCG (breast cancer-specific protein 1)
Purity/Purification
Affinity-Chromatography
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
126
Applicable Applications for anti-SNCG antibody
Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes
ELISA: 1:10000
WB: 1:500-1:2000
IHC: 1:200-1:1000
IF/ICC: 1:100-1:500
WB: 1:500-1:2000
IHC: 1:200-1:1000
IF/ICC: 1:100-1:500
Immunogen
Purified recombinant fragment of human SNCG (breast cancer-specific protein 1) expressed in E. Coli
Subcellular Location
Cytoplasm > Perinuclear Region. Cytoplasm > Cytoskeleton > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Tissue Specificity
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Figure 1: Western blot analysis using SNCG mouse mAb against truncated SNCG recombinant protein.)
Western Blot (WB)
(Figure 1: Western blot analysis using SNCG mouse mAb against truncated SNCG recombinant protein.)
Related Product Information for anti-SNCG antibody
Description: SNCG(also designated gamma-synuclein or breast cancer-specific protein 1), with 127-amino acid protein(about 14kDa), belongs to the synuclein family, which also includes alpha-and beta-synuclein.Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals, while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Subunit Structure: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation (By similarity).
Post-translational Modifications: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
Similarity: Belongs to the synuclein family.
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Subunit Structure: May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation (By similarity).
Post-translational Modifications: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
Similarity: Belongs to the synuclein family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 13 kDa
Predicted: 14 kDa
Predicted: 14 kDa
NCBI Official Full Name
gamma-synuclein isoform 2
NCBI Official Synonym Full Names
synuclein gamma
NCBI Official Symbol
SNCG
NCBI Official Synonym Symbols
SR; BCSG1
NCBI Protein Information
gamma-synuclein
UniProt Protein Name
Gamma-synuclein
Protein Family
UniProt Gene Name
SNCG
UniProt Synonym Gene Names
BCSG1; PERSYN; PRSN; SR
NCBI Description
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq, Jan 2010]
Uniprot Description
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway ().
Research Articles on SNCG
Similar Products
Product Notes
The SNCG sncg (Catalog #AAA9602384) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SNCG (breast cancer-specific protein 1) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SNCG can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA). ELISA: 1:10000 WB: 1:500-1:2000 IHC: 1:200-1:1000 IF/ICC: 1:100-1:500. Researchers should empirically determine the suitability of the SNCG sncg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNCG, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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