Mouse anti-Human NTAL Antibody | anti-NTAL antibody

Anti-NTAL Purified

Cat. Num. AAA1801394

• Gene Names: LAT2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• Reactivity: Human
• Applications: Immunoprecipitation, Western Blot, Immunohistochemistry
• Purity: Purified by Protein-A Affinity Chromatography
• Synonyms: NTAL; Anti-NTAL Purified; linker for activation of T cells family member 2; LAB; LAT2; anti-NTAL antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG2a
• Clone Number: NAP-03
• Specificity: The antibody NAP-03 recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells.
• Purity/Purification: Purified by Protein-A Affinity Chromatography
• Form/Format: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 243

• Applicable Applications for anti-NTAL antibody: Immunoprecipitation, Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Immunogen: Peptide corresponding to aa 196-212 of human NTAL coupled to KLH.
• Negative Species: Mouse
• Preparation and Storage: Store at 2-8 degree C.

Related Product Information for anti-NTAL antibody

NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.

NCBI and Uniprot Product Information

• NCBI GI #: 14702182
• NCBI GeneID: 7462
• NCBI Accession #: NP_054865.2
• NCBI GenBank Nucleotide #: NP_054865.2
• UniProt Accession #: Q9GZY6
• NCBI Official Full Name: linker for activation of T-cells family member 2
• NCBI Official Synonym Full Names: linker for activation of T cells family member 2
• NCBI Official Symbol: LAT2
• NCBI Official Synonym Symbols: LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
• NCBI Protein Information: linker for activation of T-cells family member 2
• UniProt Protein Name: Linker for activation of T-cells family member 2
• UniProt Gene Name: LAT2
• UniProt Synonym Gene Names: LAB; NTAL; WBS15; WBSCR15; WBSCR5
• UniProt Entry Name: NTAL_HUMAN

NCBI Description

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft

Molecular Function: protein binding; SH2 domain binding

Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation