Mouse anti-Human MATK Antibody | anti-MATK antibody

MATK Antibody

Cat. Num. AAA850070

• Gene Names: MATK; CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
• Reactivity: Human
• Applications: Western Blot, Flow Cytometry, Functional Assay, ELISA
• Synonyms: MATK; MATK Antibody; CHK; CTK; anti-MATK antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG1
• Clone Number: 9D7
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 508

• Applicable Applications for anti-MATK antibody: Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; FC: 1:200-1:400; ELISA: 1:10000
• Immunogen: Purified recombinant fragment of human MATK expressed in E. Coli.
• Preparation and Storage: Store at 4 degree C, for long term storage, store at-20 degree C

Western Blot (WB)

(Figure 1: Western blot analysis using MATK mouse mAb against K562 cell lysate (1).)

Flow Cytometry (FC/FACS)

(Figure 2: Flow cytometric analysis of K562 cells using MATK mouse mAb (green) and negative control (purple).)

Related Product Information for anti-MATK antibody

MATK (megakaryocyte-associated tyrosine kinase), also known as CTK, this protein has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.

Product Categories/Family for anti-MATK antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 21450842
• NCBI GeneID: 4145
• NCBI Accession #: NP_002369.2
• NCBI GenBank Nucleotide #: NM_002378.3
• UniProt Accession #: P42679; Q9NST8; B3KNZ9
• Molecular Weight: 56kDa
• NCBI Official Full Name: megakaryocyte-associated tyrosine-protein kinase isoform b
• NCBI Official Synonym Full Names: megakaryocyte-associated tyrosine kinase
• NCBI Official Symbol: MATK
• NCBI Official Synonym Symbols: CHK; CTK; HYL; Lsk; HYLTK; HHYLTK
• NCBI Protein Information: megakaryocyte-associated tyrosine-protein kinase
• UniProt Protein Name: Megakaryocyte-associated tyrosine-protein kinase
• Protein Family: Maturase
• UniProt Gene Name: MATK
• UniProt Synonym Gene Names: CTK; HYL; CHK

NCBI Description

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.