Western Blot (WB)
(MATK Antibody (M1) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MATK antibody detected the MATK protein (arrow).)
Rabbit anti-Human MATK Polyclonal Antibody | anti-MATK antibody
MATK Antibody (N-term)
Western Blot (WB)
(MATK Antibody (M1) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MATK antibody detected the MATK protein (arrow).)
Western Blot (WB)
(MATK Antibody (M1) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MATK antibody detected the MATK protein (arrow).)
Zagozdzon, R., et al., Int. J. Oncol. 21(6):1347-1352 (2002).
Zrihan-Licht, S., et al., J. Biol. Chem. 272(3):1856-1863 (1997).
Jhun, B.H., et al., J. Biol. Chem. 270(16):9661-9666 (1995).
Avraham, S., et al., J. Biol. Chem. 270(4):1833-1842 (1995).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CTK: a non-receptor tyrosine kinase. Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. Expressed in cancerous but not normal breast tissue; interacts with activated ERBB2 receptor and is likely to inhibit proliferation.
Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Csk family
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extrinsic to internal side of plasma membrane; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: cell proliferation; cell migration; positive regulation of cell proliferation; innate immune response; morphogenesis of an epithelium; mesoderm development; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation
Research Articles on MATK
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Product Notes
The MATK matk (Catalog #AAA9214519) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The MATK Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MATK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MATK matk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MATK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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