Mouse Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit | ZFHX3 elisa kit

Mouse Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit

Cat. Num. AAA9301451

• Gene Names: ZFHX3; ATBT; ATBF1; ZNF927
• Reactivity: Mouse
• Synonyms: Zinc Finger Homeobox Protein 3 (ZFHX3); Mouse Zinc Finger Homeobox Protein 3 (ZFHX3) ELISA Kit; ZFHX3 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 258613987
• NCBI GeneID: 463
• NCBI Accession #: NP_001158238.1
• NCBI GenBank Nucleotide #: NM_001164766.1
• UniProt Accession #: Q15911; O15101; Q13719; D3DWS8
• Molecular Weight: 404,419 Da
• NCBI Official Full Name: zinc finger homeobox protein 3 isoform B
• NCBI Official Synonym Full Names: zinc finger homeobox 3
• NCBI Official Symbol: ZFHX3
• NCBI Official Synonym Symbols: ATBT; ATBF1; ZNF927
• NCBI Protein Information: zinc finger homeobox protein 3; ZFH-3; AT motif-binding factor 1; AT-binding transcription factor 1; zinc finger homeodomain protein 3; alpha-fetoprotein enhancer binding protein; alpha-fetoprotein enhancer-binding protein
• UniProt Protein Name: Zinc finger homeobox protein 3
• Protein Family: Zinc finger homeobox protein
• UniProt Gene Name: ZFHX3
• UniProt Synonym Gene Names: ATBF1; ZFH-3
• UniProt Entry Name: ZFHX3_HUMAN

NCBI Description

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

ATBF1: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Transcription factor; Cell development/differentiation; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 16q22.3

Cellular Component: nucleoplasm; transcription factor complex; intracellular membrane-bound organelle; mitochondrion; nucleolus; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; enzyme binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; muscle development; regulation of transcription, DNA-dependent; regulation of neuron differentiation; negative regulation of transcription from RNA polymerase II promoter; brain development; cell cycle arrest; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; positive regulation of myoblast differentiation

Disease: Prostate Cancer