Mouse Vitamin K-Dependent Protein S (PROS1) ELISA Kit | PROS1 elisa kit

Mouse Vitamin K-Dependent Protein S (PROS1) ELISA Kit

Cat. Num. AAA9717255

• Gene Names: Pros1; AW214361
• Reactivity: Mouse
• Synonyms: Vitamin K-Dependent Protein S (PROS1); Mouse Vitamin K-Dependent Protein S (PROS1) ELISA Kit; PROS1; PROS; PS21; PS22; PS23; PS24; PS25; PSA; protein S; alpha; protein Sa; vitamin K-dependent plasma protein S; PROS1 elisa kit

• Reactivity: Mouse
• Sequence Length: 675

• Assay Type: Sandwich
• Preparation and Storage: Store at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

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Related Product Information for PROS1 elisa kit

Principle of the Assay: Mouse Vitamin K-dependent protein S (PROS1) ELISA Kit employs a two-site sandwich ELISA to quantitate PROS1 in samples. An antibody specific for PROS1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any PROS1 present is bound by the immobilized antibody. After removing any unbound substances, HRP-Conjugated Mouse PROS1 detection antibody is added to the wells. Following a wash to remove any unbound HRP reagent, a Chromogen solution is added to the wells and color develops in proportion to the amount of PROS1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Background/Introduction: PROS1 encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. Protein S (alpha) undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages.

NCBI and Uniprot Product Information

• NCBI GI #: 46309455
• NCBI GeneID: 19128
• NCBI Accession #: NP_035303.1
• NCBI GenBank Nucleotide #: NP_035303.1
• UniProt Accession #: Q08761
• NCBI Official Full Name: vitamin K-dependent protein S preproprotein
• NCBI Official Synonym Full Names: protein S (alpha)
• NCBI Official Symbol: Pros1
• NCBI Official Synonym Symbols: AW214361
• NCBI Protein Information: vitamin K-dependent protein S
• UniProt Protein Name: Vitamin K-dependent protein S
• Protein Family: Vitamin K-dependent protein
• UniProt Gene Name: Pros1
• UniProt Synonym Gene Names: Pros
• UniProt Entry Name: PROS_MOUSE

NCBI Description

This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015]

Uniprot Description

PROS1: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal dominant (THPH5). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Based on the plasma levels of total and free PROS1 antigen as well as the serine protease-activated protein C cofactor activity, three types of PROS1D have been described: type I, characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and the rare type II which is characterized by normal concentrations of both total and free PROS1 antigen, but low cofactor activity. Defects in PROS1 are the cause of thrombophilia due to protein S deficiency, autosomal recessive (THPH6). A very rare and severe hematologic disorder resulting in thrombosis and secondary hemorrhage usually beginning in early infancy. Some affected individuals develop neonatal purpura fulminans, multifocal thrombosis, or intracranial hemorrhage.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; protein complex; extracellular region

Molecular Function: protein complex binding; calcium ion binding

Biological Process: fibrinolysis; hemostasis; positive regulation of phagocytosis; negative regulation of coagulation; blood coagulation