Mouse Hepcidin (Hepc) ELISA Kit | Hepc elisa kit
Mouse Hepcidin (Hepc) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]
Uniprot Description
HAMP: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B); also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Belongs to the hepcidin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7 B1|7 19.27 cM
Cellular Component: extracellular region; extracellular space; nucleus
Molecular Function: copper ion binding; hormone activity
Biological Process: cellular iron ion homeostasis; cellular response to extracellular stimulus; defense response to bacterium; defense response to fungus; iron ion homeostasis; JAK-STAT cascade; membrane protein proteolysis; myeloid cell homeostasis; negative regulation of bone resorption; negative regulation of inflammatory response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of macrophage activation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on Hepc
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Product Notes
The Mouse Hepc hamp (Catalog #AAA2087940) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087940 ELISA Kit recognizes Mouse Hepc. It is sometimes possible for the material contained within the vial of "Hepcidin (Hepc), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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