Mouse Hepcidin (Hepc) ELISA Kit | Hepc elisa kit

Mouse Hepcidin (Hepc) ELISA Kit

Cat. Num. AAA452689

• Gene Names: Hamp; Hepc; Hamp1; Hepc1
• Reactivity: Mouse
• Synonyms: Hepcidin (Hepc); Mouse Hepcidin (Hepc) ELISA Kit; HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor; Hepc elisa kit

• Reactivity: Mouse
• Sequence Length: 83

• Samples: Serum, plasma, urine and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 62.5-4000pg/mL
• Sensitivity: 25.4pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 14211542
• NCBI GeneID: 84506
• NCBI Accession #: NP_115930.1
• NCBI GenBank Nucleotide #: NM_032541.2
• UniProt Accession #: Q9EQ21
• Molecular Weight: 9,352 Da
• NCBI Official Full Name: hepcidin preproprotein
• NCBI Official Synonym Full Names: hepcidin antimicrobial peptide
• NCBI Official Symbol: Hamp
• NCBI Official Synonym Symbols: Hepc; Hamp1; Hepc1
• NCBI Protein Information: hepcidin
• UniProt Protein Name: Hepcidin
• Protein Family: Heparin-sulfate lyase
• UniProt Gene Name: Hamp
• UniProt Synonym Gene Names: Hamp1; Hepc; Hepc1

NCBI Description

This gene encodes hepcidin, an antimicrobial peptide and master hormonal regulator of systemic iron metabolism. The encoded preproprotein is synthesized in the hepatocytes where it undergoes proteolytic processing to generate disulfide-linked mature peptides that are secreted into the bloodstream. Mice lacking the encoded protein develop multivisceral iron overlaod, with sparing of the spleen macrophages. Certain mutations in the human ortholog of this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis. This gene is located adjacent to a related hepcidin gene on chromosome 7. [provided by RefSeq, Aug 2016]

Uniprot Description

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.