Mouse Complement C5 ELISA Kit | C5 elisa kit

Mouse Complement C5 ELISA Kit

Cat. Num. AAA2882732

• Gene Names: Hc; C5; He; C5a
• Reactivity: Mouse
• Synonyms: Complement C5; Mouse Complement C5 ELISA Kit; Hemolytic complement; C5; Hc; C5 elisa kit

• Reactivity: Mouse
• Sequence Length: 1685

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.156 ng/mL
• Intra-Assay CV: <=8.4%
• Inter-Assay CV: <=10.1%
• Recovery: 98%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 930155596
• NCBI GeneID: 15139
• NCBI Accession #: NP_034536.2
• NCBI GenBank Nucleotide #: NM_010406.2
• UniProt Accession #: P06684; A2AS36
• Molecular Weight: 188,878 Da
• NCBI Official Full Name: complement C5 preproprotein
• NCBI Official Synonym Full Names: hemolytic complement
• NCBI Official Symbol: Hc
• NCBI Official Synonym Symbols: C5; He; C5a
• NCBI Protein Information: complement C5
• UniProt Protein Name: Complement C5
• Protein Family: Complement C5
• UniProt Gene Name: C5
• UniProt Synonym Gene Names: Hc
• UniProt Entry Name: CO5_MOUSE

NCBI Description

This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model. [provided by RefSeq, Nov 2015]

Uniprot Description

C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space; membrane attack complex

Molecular Function: endopeptidase inhibitor activity

Biological Process: complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune system process; in utero embryonic development; inflammatory response; innate immune response; positive regulation of angiogenesis