FABP5 recombinant protein

FABP5 Protein, Human, Recombinant

Cat. Num. AAA8121194

• Gene Names: FABP5; EFABP; KFABP; E-FABP; PAFABP; PA-FABP
• Purity: >92% as determined by SDS-PAGE
• Synonyms: FABP5; FABP5 Protein; Human; Recombinant; Human FABP5/E-FABP Protein; E-FABP Protein; EFABP Protein; KFABP Protein; PA-FABP Protein; PAFABP Protein; fatty acid binding protein 5 (psoriasis-associated); FABP5 recombinant protein

• Host: E Coli
• Purity/Purification: >92% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile 50mM Tris, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Glu135

• Species: Human
• Predicted N Terminal: Met 1
• Tag: Native
• Protein Construction: A DNA sequence encoding the human FABP5 (Q01469)(Met 1-Glu 135) was expressed and purified.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FABP5 recombinant protein

Background: Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein which Belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid-binding proteins (FABPs) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. E-FABP/FABP5 is predominantly expressed in keratinocytes and is overexpressed in the actively proliferating tissue characteristic of psoriasis and wound healing. E-FABP/FABP5 exhibits an important role in binding free fatty acids, as well as regulating lipid metabolism and transport. E-FABP/FABP5 has high specificity for fatty acids. It has highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity of FABP5. E-FABP/FABP5 may be involved in keratinocyte differentiation.

References

Hohoff C., et al., 1999, Biochemistry 38:12229-39 Gutierrez-Gonzalez L.H., et al., 2002, Biochem. J. 364:725-37. Ogawa,E. et al., 2011, J Invest Dermatol. 131 (3):604-12. Ma,X. et al., 2010, Mol Biol Rep. 37 (8):4003-11.

NCBI and Uniprot Product Information

• NCBI GI #: 232081
• NCBI GeneID: 2171
• UniProt Accession #: Q01469; B2R4K0
• Molecular Weight: 15,164 Da
• NCBI Official Full Name: Fatty acid-binding protein, epidermal
• NCBI Official Synonym Full Names: fatty acid binding protein 5 (psoriasis-associated)
• NCBI Official Symbol: FABP5
• NCBI Official Synonym Symbols: EFABP; KFABP; E-FABP; PAFABP; PA-FABP
• NCBI Protein Information: fatty acid-binding protein, epidermal; epidermal-type fatty acid-binding protein; psoriasis-associated fatty acid-binding protein homolog
• UniProt Protein Name: Fatty acid-binding protein, epidermal
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP5
• UniProt Synonym Gene Names: E-FABP; PA-FABP
• UniProt Entry Name: FABP5_HUMAN

NCBI Description

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

Uniprot Description

FABP5: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: protein binding; transporter activity; fatty acid binding; lipid binding

Biological Process: epidermis development; phosphatidylcholine biosynthetic process; glucose metabolic process; glucose transport; lipid metabolic process