Mouse CD81 Antibody | anti-CD81 antibody

Anti-Hu CD81 APC-Cyanine7

Cat. Num. AAA1800944

• Gene Names: CD81; S5.7; CVID6; TAPA1; TSPAN28
• Reactivity: Rabbit, Cat, Human
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with tandem dye APC-Cyanine7 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: CD81; Anti-Hu CD81 APC-Cyanine7; CD81 molecule; S5.7; CVID6; TAPA1; TSPAN28; anti-CD81 antibody

• Host: Mouse
• Reactivity: Rabbit, Cat, Human
• Isotype: IgG1
• Clone Number: M38
• Specificity: The antibody M38 reacts with an extracellular epitope of CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells.
• Purity/Purification: The purified antibody is conjugated with tandem dye APC-Cyanine7 under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
• Sequence Length: 236

• Applicable Applications for anti-CD81 antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: QC tested
• Immunogen: MOLT-4 (human T-ALL cell line)
• Conjugation: APC-Cyanine7
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Flow Cytometry (FC/FACS)

(Flow cytometry analysis (surface staining) of CD81 in human peripheral blood with anti-CD81 (M38) APC-CyTM7.)

Related Product Information for anti-CD81 antibody

CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.

NCBI and Uniprot Product Information

• NCBI GI #: 38503376
• NCBI GeneID: 975
• UniProt Accession #: P60033
• NCBI Official Full Name: CD81 antigen
• NCBI Official Synonym Full Names: CD81 molecule
• NCBI Official Symbol: CD81
• NCBI Official Synonym Symbols: S5.7; CVID6; TAPA1; TSPAN28
• NCBI Protein Information: CD81 antigen
• UniProt Protein Name: CD81 antigen
• Protein Family: CD81 antigen
• UniProt Gene Name: CD81
• UniProt Synonym Gene Names: TAPA1; TSPAN28; Tspan-28

NCBI Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Description

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.