GCSF active protein

GCSF protein (Mouse)

Cat. Num. AAA538014

• Gene Names: Csf3; Csfg; G-CSF; MGI-IG
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: GCSF; GCSF protein (Mouse); Granulocyte Colony-Stimulating Factor protein; MGI-1G protein; GM-CSFb protein; pluripoietin protein; CSF-3 protein; GCSF active protein

• Host: Mouse
• Purity/Purification: > 98% pure
• Form/Format: Lyophilized from 5mM sodium citrate, pH 4.0. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
• Sequence: Region of GCSF protein corresponding to amino acids MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA.
• Sequence Length: 208

• Applicable Applications for GCSF active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and Mouse G-CSF are cross-species reactive.
• Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse M-NFS-60 cells is 2 x 10^7 units/mg.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for GCSF active protein

Purified recombinant Mouse GCSF protein

Product Categories/Family for GCSF active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 6753536
• NCBI GeneID: 12985
• NCBI Accession #: NP_034101.1
• NCBI GenBank Nucleotide #: NM_009971.1
• UniProt Accession #: P09920
• Molecular Weight: 19 kDa
• NCBI Official Full Name: granulocyte colony-stimulating factor
• NCBI Official Synonym Full Names: colony stimulating factor 3 (granulocyte)
• NCBI Official Symbol: Csf3
• NCBI Official Synonym Symbols: Csfg; G-CSF; MGI-IG
• NCBI Protein Information: granulocyte colony-stimulating factor
• UniProt Protein Name: Granulocyte colony-stimulating factor
• UniProt Gene Name: Csf3
• UniProt Synonym Gene Names: Csfg; G-CSF
• UniProt Entry Name: CSF3_MOUSE

Uniprot Description

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell cycle regulation

Cellular Component: extracellular space; extracellular region

Molecular Function: enzyme binding; growth factor activity; cytokine activity

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; granulocyte differentiation; positive regulation of protein binding; positive regulation of actin filament polymerization; positive regulation of myeloid cell differentiation; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation