Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of VGLUT2 protein using Mouse Anti-VGLUT2 Monoclonal Antibody, Clone S29-29. Primary Antibody: Mouse Anti-VGLUT2 Monoclonal Antibody at 1:000.)
Mouse anti-Mouse, Rat VGlut2 Monoclonal Antibody | anti-Slc17a6 antibody
VGLUT2 Antibody: PerCP
Gene Names
Slc17a6; Dnpi; Vglut2
Reactivity
Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Synonyms
VGlut2; Monoclonal Antibody; VGLUT2 Antibody: PerCP; Differentiation associated BNPI; DNPI; SLC17A6; Solute carrier family 17 member 6; Vesicular glutamate transporter 2; Differentiation associated Na dependent inorganic phosphate cotransporter; anti-Slc17a6 antibody
Host
Mouse
Reactivity
Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
S29-29
Form/Format
Protein G Purified
Concentration
1mg/mL (varies by lot)
Sequence Length
582
Applicable Applications for anti-Slc17a6 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes
1:1000 (WB)
Conjugate
PerCP
Storage Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of VGLUT2 protein using Mouse Anti-VGLUT2 Monoclonal Antibody, Clone S29-29. Primary Antibody: Mouse Anti-VGLUT2 Monoclonal Antibody at 1:000.)
Western Blot (WB)
(Western Blot analysis of Rat brain membrane lysate showing detection of VGLUT2 protein using Mouse Anti-VGLUT2 Monoclonal Antibody, Clone S29-29. Primary Antibody: Mouse Anti-VGLUT2 Monoclonal Antibody at 1:000.)
Related Product Information for anti-Slc17a6 antibody
Background Info: Detects ~60kDa.
Scientific Background: The ATP-dependent, chloride-sensitive vesicular glutamate transporters (VGLUT) include BNPI (VGLUT1), VGLUT2 (DNPI) and VGLUT3. The brain expresses BNPI (brain specific Na+-dependent inorganic phosphate (Pi) cotransporter) and VGLUT2 in a complementary fashion. The telencephalic regions express BNPI, whereas the lower brainstem and diencephalic regions express VLGUT2. Rat pinealocytes express both BNPI and VGLUT2. The striatum, hippocampus, cerebral cortex and raphe nuclei express VGLUT3 in a small number of neurons. Pancreatic alpha and beta cells express BNPI and VGLUT2 in response to glucose concentrations. Human VGLUT3 shares a 72% sequence homology with VLGUT2 and BNPI.
Scientific Background: The ATP-dependent, chloride-sensitive vesicular glutamate transporters (VGLUT) include BNPI (VGLUT1), VGLUT2 (DNPI) and VGLUT3. The brain expresses BNPI (brain specific Na+-dependent inorganic phosphate (Pi) cotransporter) and VGLUT2 in a complementary fashion. The telencephalic regions express BNPI, whereas the lower brainstem and diencephalic regions express VLGUT2. Rat pinealocytes express both BNPI and VGLUT2. The striatum, hippocampus, cerebral cortex and raphe nuclei express VGLUT3 in a small number of neurons. Pancreatic alpha and beta cells express BNPI and VGLUT2 in response to glucose concentrations. Human VGLUT3 shares a 72% sequence homology with VLGUT2 and BNPI.
Product Categories/Family for anti-Slc17a6 antibody
References
1. Aihara Y., et al. (2000) J Neurochem. 74: 2622-2625. 2. Kaneko T., and Fujiyama F. (2002) Neurosci Res. 42: 243-250. 3. Gras C., et al. (2002) J Neurosci. 22: 5442-5451. 4. Takamori S., Malherbe P., Broger C., and Jahn R. (2002) EMBO Rep. 3: 798-803. 5. Morimoto R., Hayashi M., Yatsushiro S., Otsuka M., Yamamoto A., and Moriyama Y. (2003) J Neurochem. 84: 382-391. 6. Bai L., Zhang X., and Ghishan F.K. (2003) Am. J. Physiol. Gastrointest. Liver Physiol. 284: G808-814.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
64,576 Da
NCBI Official Full Name
vesicular glutamate transporter 2
NCBI Official Synonym Full Names
solute carrier family 17 (vesicular glutamate transporter), member 6
NCBI Official Symbol
Slc17a6
NCBI Official Synonym Symbols
Dnpi; Vglut2
NCBI Protein Information
vesicular glutamate transporter 2; differentiation-associated BNPI; solute carrier family 17 member 6; differentation-associated Na-dependent inorganic phosphate cotransporter; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
UniProt Protein Name
Vesicular glutamate transporter 2
Protein Family
UniProt Gene Name
Slc17a6
UniProt Synonym Gene Names
Dnpi; Vglut2; VGluT2
UniProt Entry Name
VGLU2_RAT
NCBI Description
Na+-dependent inorganic phosphate cotransporter; involved in Ca2+-dependent glutamate release from astrocytes [RGD, Feb 2006]
Uniprot Description
SLC17A6: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family
Cellular Component: synaptic vesicle; neuron projection; synaptic vesicle membrane; early endosome; integral to membrane; cell junction
Molecular Function: symporter activity; L-glutamate transmembrane transporter activity
Biological Process: sodium ion transport; neurotransmitter uptake
Research Articles on Slc17a6
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Product Notes
The Slc17a6 slc17a6 (Catalog #AAA802659) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The VGLUT2 Antibody: PerCP reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's VGlut2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). 1:1000 (WB). Researchers should empirically determine the suitability of the Slc17a6 slc17a6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VGlut2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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