Western Blot (WB)
(Western blot analysis of TWEAKR on different lysates using anti-TWEAKR antibody at 1/1, 000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: C2C12)
Rabbit TWEAKR Monoclonal Antibody | anti-TWEAKR antibody
TWEAKR Antibody
Gene Names
TNFRSF12A; FN14; CD266; TWEAKR
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunoprecipitation
Purity
ProA affinity purified
Synonyms
TWEAKR; Monoclonal Antibody; TWEAKR Antibody; CD 266 antibody; CD266 antibody; CD266 antigen antibody; FGF inducible 14 antibody; FGF-inducible 14 antibody; Fibroblast growth factor inducible immediate early response protein 14 antibody; Fibroblast growth factor-inducible immediate-early response protein 14 antibody; FN 14 antibody; FN14 antibody; TNFRSF 12A antibody; TNFRSF12A antibody; TNR12_HUMAN antibody; Tumor necrosis factor receptor superfamily member 12A antibody; TWEAK R antibody; Tweak receptor antibody; Tweak-receptor antibody; TweakR antibody; anti-TWEAKR antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Clone Number
SN20-07
Purity/Purification
ProA affinity purified
Form/Format
1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-TWEAKR antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Antibody Type
Recombinant Antibody
Immunogen
Recombinant protein
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.
Western Blot (WB)
(Western blot analysis of TWEAKR on different lysates using anti-TWEAKR antibody at 1/1, 000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: C2C12)
Western Blot (WB)
(Western blot analysis of TWEAKR on different lysates using anti-TWEAKR antibody at 1/1, 000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: C2C12)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-TWEAKR antibody. Counter stained with hematoxylin.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-TWEAKR antibody. Counter stained with hematoxylin.)
Related Product Information for anti-TWEAKR antibody
Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.
Product Categories/Family for anti-TWEAKR antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
10,191 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol
TNFRSF12A
NCBI Official Synonym Symbols
FN14; CD266; TWEAKR
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
UniProt Gene Name
TNFRSF12A
UniProt Synonym Gene Names
FN14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_HUMAN
Uniprot Description
TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane
Molecular Function: protein binding
Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis
Research Articles on TWEAKR
Similar Products
Product Notes
The TWEAKR tnfrsf12a (Catalog #AAA9435882) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TWEAKR Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TWEAKR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP). WB: 1:500-1:1000 IHC: 1:50-1:200 . Researchers should empirically determine the suitability of the TWEAKR tnfrsf12a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TWEAKR, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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