Mouse anti-Human, Mouse TMEM70 Monoclonal Antibody | anti-TMEM70 antibody

TMEM70 Mouse Monoclonal

Cat. Num. AAA7605022

• Gene Names: TMEM70; MC5DN2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: TMEM70; Monoclonal Antibody; TMEM70 Mouse Monoclonal; anti-TMEM70 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 107

• Applicable Applications for anti-TMEM70 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Transmembrane protein 70
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver using MBS7605022 (TMEM70 antibody) at dilution of 1:50)

Western Blot (WB)

(A2780 cells were subjected to SDS PAGE followed by western blot with MBS7605022 (TMEM70 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 95007020
• NCBI GeneID: 54968
• NCBI Accession #: NP_001035703.1
• NCBI GenBank Nucleotide #: NM_001040613.2
• Molecular Weight: 11,278 Da
• NCBI Official Full Name: transmembrane protein 70, mitochondrial isoform b
• NCBI Official Synonym Full Names: transmembrane protein 70
• NCBI Official Symbol: TMEM70
• NCBI Official Synonym Symbols: MC5DN2
• NCBI Protein Information: transmembrane protein 70, mitochondrial
• UniProt Protein Name: Transmembrane protein 70, mitochondrial
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM70
• UniProt Entry Name: TMM70_HUMAN

NCBI Description

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Uniprot Description

TMEM70: Involved in biogenesis of mitochondrial ATP synthase. Defects in TMEM70 are a cause of mitochondrial complex V deficiency nuclear type 2 (MC5DN2). A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. Belongs to the TMEM70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: mitochondrial inner membrane; mitochondrion; nucleoplasm

Biological Process: mitochondrial proton-transporting ATP synthase complex assembly

Disease: Mitochondrial Complex V (atp Synthase) Deficiency, Nuclear Type 2