Mouse Thyroglobulin Monoclonal Antibody | anti-TG antibody

Thyroglobulin (T3/T4) Monoclonal Antibody

Cat. Num. AAA190444

• Gene Names: TG; TGN; AITD3
• Applications: Immunoassay
• Synonyms: Thyroglobulin; Monoclonal Antibody; Thyroglobulin (T3/T4) Monoclonal Antibody; Anti-Thyroglobulin; anti-TG antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgM
• Specificity: Anti-Thyroglobulin. Murine MAbs recognize human thyroglobulin. Recognize T3 and T4.
• Form/Format: 1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4
• Sequence Length: 2768

• Applicable Applications for anti-TG antibody: Immunoassay
• Application Notes: These antibodies may be used inimmunoassays to detect and quantitatethyroglobulin. Other applications areunder investigation.
• Antigen: Purified human thyroglobulin.
• Activity: Ig mg/ml* : 7.4; ELISA Titer**: 1: 25,600; (Note: * Determined by radial immunodiffusionfor several lots of ascites.; **ELISA is an indirect assay againstthyroglobulin on the solid phase. Titers represent endpoint dilutions that achieveabsorbance values >= 0.1.)
• Stabilizer: None
• Preservatives: None. Available on request.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: These antibodies are stable for at leastone (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Product Categories/Family for anti-TG antibody

Hormone and Serum Protein Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 37174
• NCBI GeneID: 7038
• UniProt Accession #: P01266; O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3; Q59GF0; Q9NYD9; Q9NYM1
• Molecular Weight: 304,790 Da
• NCBI Official Full Name: thyroglobulin
• NCBI Official Synonym Full Names: thyroglobulin
• NCBI Official Symbol: TG
• NCBI Official Synonym Symbols: TGN; AITD3
• NCBI Protein Information: thyroglobulin; OTTHUMP00000227159
• UniProt Protein Name: Thyroglobulin
• Protein Family: Thyroglobulin
• UniProt Gene Name: TG
• UniProt Entry Name: THYG_HUMAN

NCBI Description

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq]

Uniprot Description

TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process

Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3